13 Proven Ways Saunas Can Improve Your Mental Health

When it comes to improving your mental health, some of the simplest strategies can have a huge impact.

Using a sauna regularly is one of them.

Infrared saunas in particular are becoming increasingly popular, and for good reason. 

They have a number of brain and mental health benefits, as discussed in the book Sauna Therapy by Dr. Lawrence Wilson.

However, you don’t necessarily need an infrared sauna to experience health benefits. Even traditional saunas – available at most public gyms, spas and health centres – have a number of beneficial cognitive and psychological effects. 

Once you start using a sauna, you should listen to your body to determine how much time you should spend in it. Start out slowly and increase the length of your sessions over time. Also make sure to drink lots of water before and after each session, and never consume alcohol in combination.

Read on to learn about the 13 ways traditional and infrared saunas can improve your brain and mental health.

1. Saunas Improve Mood and Reduce Depression

Saunas can really help people that struggle with depression.

Lots of research shows that they can make you feel euphoric. Saunas are somewhat stressful on the body, so your brain produces and releases more euphoric hormones to deal with it (53-55).

And these changes appear to be semi-permanent (56). 

So if you use a sauna regularly, you'll end up being consistently happy. 

Dr. Jeffrey Lieberman, MD, has completed two studies in which he had people with major depression sit in an infrared sauna.

In his first study, the participants had just one infrared sauna treatment and it reduced their symptoms by about 50%.

In his follow-up study, he found that a single session caused a rapid and powerful antidepressant effect, and the benefits continued for six weeks, which was unexpected. 

He concluded that whole-body hyperthermia holds promise as a safe, rapid-acting, antidepressant treatment with a prolonged therapeutic benefit (57-58). 

Other researchers have looked at the effects of infrared sauna therapy on mildly depressed patients with fatigue, appetite loss, and mental complaints. They found that sauna treatment significantly increased their appetite and reduced their mental complaints (59). 

Whole-body heat therapy has also been shown to reduce depression in cancer patients (60-61).

And other research shows that sweating increases mental satisfaction and energy (62). 

2. Saunas Reduce Anxiety and Stress

Not surprisingly, saunas can also reduce stress and anxiety.

Several studies have shown that regular sauna use lowers levels of cortisol, your body’s main stress hormone (49-52). 

In one study, researchers found that using a sauna can reduce both state and trait anxiety (48).

And other research shows that sweating increases relaxation, and reduces feelings of frustration and anxiety (62). 

Here are 21 other ways to reduce cortisol and increase your resilience to stress.

3. Saunas Increase Beta-Endorphins, Relieve Pain and Help Treat Fibromyalgia

Beta-endorphins are pain-relieving compounds that originate within your body. 

Your brain produces and releases these natural painkillers during times of strenuous exercise, emotional stress and pain.

Since saunas are a stressor, the release of endorphins are increased when you spend time in one.

Several studies have shown that heat stress and heat exposure in a dry sauna cause a significant increase in beta-endorphin levels (28-32). 

This may explain why research shows that sauna therapy can lessen the pain experienced by patients with fibromyalgia, a chronic syndrome characterized by widespread pain with tenderness in specific areas.

In one study, people with fibromyalgia experienced a 33 to 77 per cent reduction in pain after using an infrared sauna regularly. Six months after the study was done, the participants still reported a 28 to 66 per cent reduction in pain (35). 

Other researchers have found the same thing and concluded that infrared sauna therapy is effective for the treatment of fibromyalgia (33-34). 

Another way to relieve pain is by taking DL-Phenylalanine. It’s an amino acid that inhibits the breakdown of endorphins. I previously wrote about it here.

4. Saunas Increase Brain-Derived Neurotrophic Factor (BDNF)

Brain-derived neurotrophic factor (BDNF) is a naturally-occurring protein in the brain that lowers your risk of mental disease and improves your mood. It does this by protecting and repairing your brain cells and increasing the growth of new brain cells. Many researchers consider it a natural antidepressant because it can reduce anxiety and depression (5-13, 15).

Research suggests that if you struggle with mental illness, you likely have reduced levels of BDNF. But luckily, there are ways to boost it.

Using a sauna is one of the ways. 

Research shows that heat exposure increases the expression of BDNF (14). 

I previously provided 21 other ways to boost BDNF in this post. 

5. Saunas Increase Norepinephrine Levels and May Help Treat Attention Deficit Hyperactivity Disorder (ADHD)

Norepinephrine, also called noradrenaline, is a hormone and neurotransmitter in the brain that can help with focus and attention.

Numerous studies have found that sauna use significantly increases norepinepherine levels (39-42). 

In one study, women spent 20 minutes in a sauna, two times each week, and researchers witnessed an 86% increase in norepinephrine (43). 

In another study, men that stayed in a sauna until exhaustion increased their norepinephrine levels by 310% (44-45). 

Besides increasing norepinephrine, heat stress also increases your body’s ability to store norepinephrine for later release (46). 

Medications that increase the reuptake norepinephrine are often prescribed to people with ADHD, so researchers believe that sauna therapy should be considered as an alternative treatment (47). 

6. Saunas Encourage the Growth of Myelin

Myelin is a fatty, white substance that wraps around the end of many nerve cells. It forms an electrically insulating sheath that increases nerve condition speeds.

In other words, it allows your brain to send information faster and more efficiently, making it absolutely essential for the optimal functioning of your nervous system.

Heat stress increases prolactin, a hormone that promotes the production of myelin (16-19). 

In one study, researchers had healthy young men stay in a sauna until they were exhausted, and they reported a 10-fold increase in prolactin (20-11). 

In another study, women spent 20 minutes sauna, two times each week, and researchers witnessed a 510% increase in prolactin (22). 

I previously provided 25 other ways to promote the growth of myelin in this post. 

7. Saunas Reduce the Risk of Dementia

Dementia is obviously a major concern today. 

It’s the third leading cause of death in the United States behind cardiovascular disease and cancer, and by 2050, it’s estimated that 13 million Americans and 160 million people globally will be affected by the disease (63).

There is currently a lack of effective treatment options, so simple tools to help with prevention are crucial.

It turns out that sauna therapy may be one of these tools.

Researchers tracked the health of more than 2,300 men in Finland for about 20 years. The men who used a sauna four to seven times each week had a 66 percent lower chance of developing dementia than men who used a sauna just once a week (64-68). 

“We have taken into account other lifestyle factors, like physical activity and socioeconomic factors. There is an independent effect of sauna.”

— Dr. Jari Laukkanen, Professor of Clinical Medicine at the University of Eastern Finland

I previously provided some other ways to reverse cognitive decline and dementia in this post. 

Intranasal insulin can also help. 

8. Saunas Reduce Psychological Symptoms of Anorexia

Anorexia nervosa, or simply known as anorexia, is an eating disorder characterized by a low weight, fear of gaining weight, a strong desire to be thin, and food restriction.

Researchers have examined the effects of sweating on anorexia and reported positive effects on hyperactivity, depression, and stress levels (27). 

9. Saunas Reduce Symptoms of Chronic Fatigue

Chronic fatigue syndrome is a complex, incapacitating illness. It affects millions of people around the world and may affect up to 4 million people in the United States alone. 

People struggling with this disorder not only have unrelenting fatigue lasting for 6 months or more, but also memory and concentration deficits, sleep disturbances, headaches, joint and muscle pain, and gastrointestinal and immune system dysfunction.

One study found that infrared sauna sessions significantly reduce fatigue in patients with chronic fatigue syndrome. It also significantly reduced their anxiety and depression (23). 

I've had some clients with chronic fatigue say that their doctor recommended they stay out of the sun and avoid exposing themselves to too much heat. But the above study didn't find any negative effects in chronic fatigue patients from regular infrared sauna sessions (23). 

Another study found that daily infrared sauna sessions dramatically improved symptoms of chronic fatigue syndrome, including fatigue, pain and sleep disturbances. The patients in the study didn’t improve with prednisolone, a steroid medication, but did improve with sauna therapy (24).

So if you struggle with chronic fatigue, infrared sauna therapy is definitely worth looking into. 

10. Saunas Reduce Tension Headaches

"Chronic tension-type headache" is a syndrome characterized by frequent headaches that occur more than 15 days every month. 

The intensity and duration of the headaches can be very distressing and disabling and affect a person's well-being.

But research shows that regular sauna use is a simple, self-directed treatment that is effective for reducing headache pain intensity (26). 

11. Saunas Help Eliminate Heavy Metals

Some of the benefits of sauna usage occur because of increased sweating. 

Many people don’t sweat very much, and this can cause problems because your skin acts as an important route of detoxification and helps you excrete heavy metals that are so prevalent in your modern environment. Common heavy metals in our environment include cadmium, arsenic, lead and mercury (36, 37). 

Lack of sweating may actually result in increased toxic load over time, which can negatively affect your brain and mental health.

Research shows that mercury poisoning from dental amalgam affects the mind and emotions and plays a role in the development of mental illness (1). 

But by sweating frequently in a sauna, you can enhance your detoxification pathways and help your body remove mercury (2, 4). 

In fact, studies show that high mercury levels can be reduced to normal levels by using a sauna repeatedly (3). 

Researchers have concluded that “sweat-inducing sauna use can provide a therapeutic method to increase elimination of toxic trace metals and should be the initial and preferred treatment of patients with elevated mercury levels” (38). 

“Sweating offers potential and deserves consideration to assist with removal of toxic elements from the body.”

— Researchers writing in the Journal of Environmental and Public Health

12. Saunas Increase Deep Sleep

Getting high-quality deep sleep is critical for optimal brain function and mental health. 

And using a sauna regularly is one way to improve it. 

Researchers in Finland report that sauna use is one of the factors that can result in deeper, more restful sleep (25). 

This sleep supplement contains magnesium and a number of other natural compounds that I’ve used over the years to deepen sleep.

But I work with my clients so that they can naturally maximize the quality of their sleep without so many supplements. We have free online workshop that talks about how you can work with us. You can register for the workshop here.

13. Saunas Support Thyroid Function

Your thyroid is a small butterfly-shaped gland located in your neck below your Adam’s apple, and lots of research shows that thyroid dysfunction can contribute to mental health problems. 

One of the main threats to the health of your thyroid is non-biological halogens. These include bromine, fluorine, chlorine, and perchlorate, which are often found in tap water.

Your thyroid doesn’t know the difference these halogens and iodine, a trace mineral necessary for proper thyroid function.

Your thyroid soaks up the halogens and uses them like iodine. By occupying iodine receptors, they inhibit the production of your thyroid hormones, and contribute to thyroid dysfunction.

But don’t worry – sauna use can help your body excrete halogens (69). 

The more you can excrete the halogens, the more your body will be able to use iodine to produce thyroid hormones.

I also recommend reducing your exposure by filtering your drinking and shower water. Brita filters aren't enough because they don’t remove fluoride. I use a Berkey water filter to make sure I’m drinking the purest water available. It filters everything out of the water. I also use this filter to remove chlorine from my shower water. 

I highly recommend getting a full thyroid panel done regularly.

Check out this post for more ways to support your thyroid. 

Conclusion

As you can see, saunas have a number of beneficial effects on the brain and can help you manage and overcome your mental health challenges. 

I’ve been doing a lot of research into saunas recently and have concluded that infrared saunas have additional benefits and are much more gentle and effective than the traditional “hot rock” saunas.

Unfortunately, most infrared saunas emit unsafe levels of electromagnetic fields (EMFs).

However, I did find a company that has a patent on low-EMF infrared saunas. Their saunas are also very well built and have a lifetime warranty. So I'm going to go with one of their saunas. You can get one here. 

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References:

(1) https://www.ncbi.nlm.nih.gov/pubmed/2618948

(2) https://www.ncbi.nlm.nih.gov/pubmed/22315626/

(3) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312275/

(4) https://www.ncbi.nlm.nih.gov/pubmed/3218899/

(5) http://www.hindawi.com/journals/tswj/2009/624894/abs/

(6) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504526/

(7) http://www.sciencedirect.com/science/article/pii/S0006322303001811

(8) http://www.sciencedirect.com/science/article/pii/0896627391902733

(9) http://www.sciencedirect.com/science/article/pii/S0166432812006997

(10) http://www.sciencedirect.com/science/article/pii/S0006899306027144

(11) http://www.ncbi.nlm.nih.gov/pubmed/25568448

(12) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC23964/

(13) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23964/

(14) https://www.ncbi.nlm.nih.gov/pubmed/21385602

(15) https://www.ncbi.nlm.nih.gov/pubmed/20594764

(16) http://www.ncbi.nlm.nih.gov/pubmed/2830109

(17) https://www.ncbi.nlm.nih.gov/pubmed/15234248

(18) https://www.ncbi.nlm.nih.gov/pubmed/17314279

(19) https://link.springer.com/article/10.1007%2FBF00691246

(20) https://www.ncbi.nlm.nih.gov/pubmed/11165553

(21) https://www.ncbi.nlm.nih.gov/pubmed/2759081

(22) https://www.ncbi.nlm.nih.gov/pubmed/2830109

(23) https://www.ncbi.nlm.nih.gov/pubmed/25748743

(24) http://www.ncbi.nlm.nih.gov/pubmed/15992574/

(25) https://www.ncbi.nlm.nih.gov/pubmed/3363395

(26) https://www.ncbi.nlm.nih.gov/pubmed/25636135

(27) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041851

(28) https://www.ncbi.nlm.nih.gov/pubmed/11165553

(29) https://www.ncbi.nlm.nih.gov/pubmed/2759081

(30) https://www.ncbi.nlm.nih.gov/pubmed/3002937

(31) https://www.ncbi.nlm.nih.gov/pubmed/8061252

(32) https://www.ncbi.nlm.nih.gov/pubmed/3218898

(33) https://www.jstage.jst.go.jp/article/internalmedicine/47/16/47_16_1473/_pdf

(34) https://www.jstage.jst.go.jp/article/internalmedicine/47/16/47_16_1473/_article

(35) https://www.ncbi.nlm.nih.gov/pubmed/21742283

(36) https://www.hindawi.com/journals/jeph/2012/184745/

(37) https://www.hindawi.com/journals/jeph/2012/184745/

(38) https://www.hindawi.com/journals/jeph/2012/184745/

(39) http://www.ncbi.nlm.nih.gov/pubmed/2759081

(40) http://www.ncbi.nlm.nih.gov/pubmed/2830109

(41) https://link.springer.com/article/10.1007%2FBF00691246

(42) https://www.ncbi.nlm.nih.gov/pubmed/15234248

(43) https://www.ncbi.nlm.nih.gov/pubmed/2830109

(44) https://www.ncbi.nlm.nih.gov/pubmed/11165553

(45) https://www.ncbi.nlm.nih.gov/pubmed/2759081

(46) https://www.ncbi.nlm.nih.gov/pubmed/4008413

(47) https://www.ncbi.nlm.nih.gov/pubmed/12621106

(48) https://www.ncbi.nlm.nih.gov/pubmed/18396259

(49) http://www.ncbi.nlm.nih.gov/pubmed/3788622

(50) http://www.ncbi.nlm.nih.gov/pubmed/2759081

(51) https://www.ncbi.nlm.nih.gov/pubmed/11165553

(52) https://www.ncbi.nlm.nih.gov/pubmed/2759081

(53) https://www.ncbi.nlm.nih.gov/pubmed/3002937

(54) https://www.ncbi.nlm.nih.gov/pubmed/8061252

(55) https://www.ncbi.nlm.nih.gov/pubmed/3218898

(56) http://www.ncbi.nlm.nih.gov/pubmed/9103537

(57) https://www.ncbi.nlm.nih.gov/pubmed/27172277

(58) http://blogs.webmd.com/mental-health/2016/07/can-sitting-in-a-sauna-ease-depression.html

(59) https://www.ncbi.nlm.nih.gov/pubmed/16046381

(60) http://www.ncbi.nlm.nih.gov/pubmed/1607735

(61) http://www.tandfonline.com/doi/abs/10.3109/02656739209021785?journalCode=ihyt20

(62) http://digital.library.okstate.edu/etd/umi-okstate-1543.pdf

(63) https://www.ncbi.nlm.nih.gov/pubmed/24598707/

(64) https://academic.oup.com/ageing/article-abstract/46/2/245/2654230/Sauna-bathing-is-inversely-associated-with

(65) https://www.sciencedaily.com/releases/2016/12/161216114143.htm

(66) http://www.foxnews.com/health/2017/01/20/sweating-in-sauna-might-help-keep-brain-healthy-finnish-study.html

(67) http://www.ctvnews.ca/health/studies-show-saunas-can-protect-against-heart-brain-diseases-1.3232765

(68) https://www.psychologytoday.com/blog/the-athletes-way/201612/frequent-sauna-use-may-reduce-risk-dementia-study-finds

(69) http://fitness.mercola.com/sites/fitness/archive/2016/09/09/sauna-bathing.aspx

(70) http://articles.mercola.com/sites/articles/archive/2014/05/04/detoxification-program.aspx

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Can Bifidobacterium Probiotics Help With Depression? A New Study Says Yes

A recent study has just been published showing that probiotics can reduce depression in humans, providing further evidence that the bacteria in your gut can affect your mood. 

It is estimated that 500 to 1,000 species of bacteria live in the human gut. They help with digestion and the proper functioning of the gastrointestinal tract.

But an increasing amount of research suggests that they also communicate with your brain and affect your behaviour. 

In a new randomized, double-blind, placebo-controlled trial, Canadian researchers at McMaster University studied whether one specific strain of beneficial gut bacterium – bifidobacterium longum – would affect patients with depression.

The researchers took 44 adults with irritable bowel syndrome (IBS) and mild to moderate depression, and randomly assigned them to two groups. One group was given the probiotic bifidobacterium longum every day for 6 weeks. The other was given placebo for 6 weeks. 

Patients filled out a questionnaire at the beginning and end of the study, which allowed researchers to determine each participant’s level of depression and quality of life. 

What’s interesting about this study is that researchers also performaned a Functional Magnetic Resonance Imaging (fMRI) test before and after the study. This allowed them to assess how the probiotic affected brain activation patterns.  

What Were The Results?

At the end of the study, 64% of patients taking the probiotic bifidobacterium longum had a significant reduction in their depression, compared to just 32% of patients given placebo. Their quality of life score also increased

And the fMRI analysis showed that multiple brain areas that are associated with depression, including the amygdala and fronto-limbic regions, were less active. The probiotic bifidobacterium longum actually reduced their reaction to “negative emotional stimuli”. In other words, they weren't as negatively affected by sad experiences and images. 

“What we found was that the patients that were treated with this probiotic bacterium improved their gut symptoms but, also surprisingly, decreased their depression scores. That means their mood improved. And this was associated also with changes in the brain imaging.

This study shows that consumption of a specific probiotic can improve both gut symptoms and psychological issues in IBS. This opens new avenues not only for the treatment of patients with functional bowel disorders but also for patients with primary psychiatric diseases.”

— Dr. Premysl Bercik, Associate Professor of Medicine at McMaster University

Even four weeks after the study had concluded, depression scores were still reduced in the patients who had been given the probiotic bifidobacterium longum.

Researchers concluded that the probiotic bifidobacterium longum can reduce depression and increase quality of life. And these improvements were associated with changes in brain activation patterns.

So if you currently struggle with depression, I think supplementing with bifidobacterium longum is worth a try. 

Bifidobacterium longum is included in the Optimal Biotics supplement.

I created Optimal Biotics because I want to give my clients and readers the very best probiotic supplement so that they can experience superior results.

I have found that many probiotic supplements on the market fall short and even cause side effects.

But Optimal Biotics doesn't, and it contains the 8 most well-researched and beneficial probiotic strains for your mental health.

In the future, I imagine practitioners will be able to use genome sequencing techniques to determine the microbiome profiles of individuals, which could then be tweaked with probiotics. In other words, there may come a day when we can "biohack" our gut bacteria for optimal mental health.

In the meantime, you can try supplementing with bifidobacterium longum, and if you’re interested in learning more about this new study, you can read the entire abstract at the end of this post.

Other Research on Bifidobacterium Longum

This isn’t the first time that the probiotic bifidobacterium longum has been linked to reductions in depression and improvements in mental health.

Here are some other studies:

• In a double-blind, placebo-controlled, randomized study, participants with mild depression took a probiotic that contained bifidobacterium longum and lactobacillus helveticus for 30 days. At the end of the study, the participants had a significantly reduction in depression, cortisol, anger, self-blame, and overall psychological distress. They also displayed higher problem-solving skills.

• In another double-blind, placebo-controlled, randomized study, healthy volunteers took bifidobacterium longum and lactobacillus helveticus for 30 days, and the results showed a reduction in psychological stress and cortisol levels.

• In an animal study, bifidobacterium longum improved learning and memory during cognitive tests.

• In a study of mice under chronic psychological stress, bifidobacterium longum and lactobacillus helveticus reduced cell death in the emotion-processing parts of their brains. It did this by reducing stress hormones and increasing brain-derived neurotrophic factor (BDNF), a protein in the brain that can help reduce depression. Another animal study also found that bifidobacterium longum increases BDNF.

• In a study of mice, bifidobacterium longum reduced schizophrenic behaviour.

Conclusion 

Conventional medicine tries to correct depression by relying on medications. But unfortunately this often ends up creating new chemical imbalances and nutrient deficiencies. 

Supplementation with bifidobacterium longum is a more evidence-based approach.

Human and animal studies show that the probiotic causes favourable biochemical and behavioural changes, leading to significant decreases in symptoms of depression.

For anyone experiencing depression, supplementing with it seems worthwhile and may allow you to reduce your reliance on prescription medication.

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Probiotic Bifidobacterium longum Reduces Depression Scores and Alters Brain Activity: a Pilot Study in Patients With Irritable Bowel Syndrome.

Abstract

BACKGROUND & AIMS:

Probiotics can reduce symptoms of irritable bowel syndrome (IBS), but little is known about their effects on psychiatric comorbidities. We performed a prospective study to evaluate the effects of Bifidobacterium longum (BL) on anxiety and depression in patients with IBS.

METHODS:

We performed a randomized, double-blind, placebo-controlled study of 44 adults with IBS and diarrhea or a mixed-stool pattern (based on Rome III criteria) and mild to moderate anxiety and/or depression (based on the Hospital Anxiety and Depression scale) at McMaster University in Canada, from March 2011 to May 2014. At the screening visit, clinical history and symptoms were assessed and blood samples were collected. Patients were then randomly assigned to groups and given daily BL (n=22) or placebo (n=22) for 6 weeks. At week 0, 6 and 10, we determined patients' levels of anxiety and depression, IBS symptoms, quality of life, and somatization using validated questionnaires. At week 0 and 6, stool, urine and blood samples were collected, and functional magnetic resonance imaging (fMRI) test was performed. We assessed brain activation patterns, fecal microbiota, urine metabolome profiles, serum markers of inflammation, neurotransmitters and neurotrophin levels.

RESULTS:

At week 6, 14/22 patients in the BL group had reduction in depression scores of 2 points or more on the Hospital Anxiety and Depression scale, vs 7/22 patients in the placebo group (P=.04). BL had no significant effect on anxiety or IBS symptoms. Patients in the BL group had a mean increase in quality of life score compared with the placebo group. The fMRI analysis showed that BL reduced responses to negative emotional stimuli in multiple brain areas, including amygdala and fronto-limbic regions, compared with placebo. The groups had similar fecal microbiota profiles, serum markers of inflammation, and levels of neurotrophins and neurotransmitters, but the BL group had reduced urine levels of methylamines and aromatic amino acids metabolites. At week 10, depression scores were reduced in patients given BL vs placebo.

CONCLUSION:

In a placebo-controlled trial, we found that the probiotic BL reduces depression but not anxiety scores and increases quality of life in patients with IBS. These improvements were associated with changes in brain activation patterns that indicate that this probiotic reduces limbic reactivity. 

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31 Proven Ways to Increase BDNF, Your Brain's Growth Hormone

Just like some people are able to drop massive amounts of weight and never gain it back, you can drop your chronic depression, anxiety and poor cognition and never have it consume you again. 

One way to do this is by increasing brain-derived neurotrophic factor, also known as BDNF.

BDNF is a naturally-occurring protein in the brain that improves brain function and lowers your risk of mental disease. 

BDNF protects and repairs your brain cells, increases the growth of new brain cells, and improves learning, memory and mood. In fact, many researchers consider it a natural antidepressant (12-17, 66).

Research suggests that if you struggle with mental illness or poor brain function, you likely have reduced levels of BDNF. But luckily, there are ways to boost it. And by doing so, you can reverse depression and protect yourself from Alzheimer’s disease (46-50, 31, 64-65, 67).

After suffering two concussions, living in a moldy house, and falling into a deep depression in 2010, I started searching far and wide for ways to boost BDNF and heal my damaged brain.

Below are 31 ways that significantly helped me, and they likely will help you too.

The Best Foods, Nutrients and Natural Supplements to Increase BDNF Levels in the Brain

1. Coffee Fruit Concentrate

Whole coffee fruit has a number of brain health benefits.

It includes the flesh of the berry that surrounds the coffee bean. 

Traditionally, the coffee bean is extracted for roasting, and the surrounding fruit is discarded.

But this is a problem because the coffee fruit contains several healthy compounds not found in coffee beans themselves.

After years of careful clinical research, scientists have discovered that ingesting whole coffee fruit concentrate significantly increases BDNF in humans. 

One study found that 100mg of whole coffee fruit concentrate increases BDNF by an astounding 143%.

And another study found that it doubles the amount of BDNF in the blood.

Coffee fruit concentrate is included in the Optimal Brain supplement. 

2. Curcumin

Curcumin is the most heavily researched compound found within turmeric, the spice that gives curry its yellow colour.

It’s one of my favourite compounds for the brain.

Studies show that it can increase BDNF production in the brain, leading to improved cognition and mood (18- 20, 22). 

It also protects the brain by activating BDNF (21). 

There are several different forms of “bioavailable” curcumin and I've tried most of them. 

I included my favourite forms in the Optimal Energy supplement.

3. Green Tea

Drinking green tea is another way you can increase BDNF. 

The antioxidants within it have been shown to increase BDNF (25). 

You can either drink green tea on a regular basis or consider taking a supplement that includes a concentrated green tea extract.

Green tea extract is included in this supplement.

4. Omega-3 Fatty Acids

A large number of people are deficient in omega-3 fatty acids today, and they are necessary for the normal electrical functioning of your brain and nervous system (70). 

They've been shown to improve mood, sleep, learning and memory, and protect against psychiatric disorders including depression, mild cognitive impairment, dementia and Alzheimer's disease (31-33).

This is likely because they've been shown to increase BDNF levels (71). 

After traumatic brain injury, omega-3s normalize BDNF levels in rats. Without supplementation, levels did not return to baseline (68). 

And omega-3 fatty acids have been shown to help patients with bipolar, likely because they support optimal BDNF levels (69). 

Yet most people don't consume enough omega-3 fatty acids through their diet.

That's why I recommend people supplement with krill oil, a special kind of fish oil that contains the essential omega-3 fatty acids.

5. Resveratrol

Resveratrol is a beneficial antioxidant compound found in red wine. 

It’s also known to help prevent the development neurodegenerative diseases.

And science is starting to understand why. 

For one, it has neuroprotective effects by elevating BDNF (37). 

Because of this increase, it can be effective at improving fatigue (38). 

That’s why I included in the Optimal Energy supplement.

6. Prebiotics and Resistant Starch

Prebiotics are substances that humans can't digest, so they pass through our gastrointestinal tract and promote the growth of many different strains of good bacteria in our lower bowel.

Essentially, they are food for the good bacteria in our intestines.

Bacteria convert prebiotics into butyrate, a substance that has been shown to increase BDNF (43, 44) 

Prebiotic-rich foods include sweet potatoes, carrots, onions, asparagus and squash. These foods are included in my free grocery shopping guide for optimal brain health and you should try to eat them as much as possible.

Resistant starch is one of the most potent ways to boost your prebiotic intake. 

A convenient way to incorporate more resistant starch into your diet is by using Unmodified Potato Starch. I take it on a regular basis. It's one of the easiest and cheapest ways to incorporate more resistant starch into your diet. It is bland so you can simply add it to beverages, smoothies and meals. It has to stay raw though, so don’t cook it.

I discussed prebiotics and resistant starch in this previous article.

Other high-quality resistant starches include banana flour, plantain flour and waxy maize. I usually rotate between them.

Cooked and cooled white rice and potatoes also contain some resistant starch. 

7. Magnesium

Magnesium has been shown to cause antidepressant effects by significantly increasing BDNF expression in the brain (51, 52). 

It’s one of the three nutrients that everyone should be taking for their brain, as most people are deficient. 

The good news is that you can easily correct magnesium deficiency yourself.

Supplementation can restore the mineral to healthy levels. 

8. Lithium Orotate

Lithium is predominantly known as a medication given to bipolar patients to manage their symptoms. 

However, it’s also an essential mineral.

Bipolar patients are often given high doses of lithium carbonate.

But low doses of lithium orotate has been shown to improve mood and have neuroprotective effects in people without bipolar disorder, and some studies have shown that it increases BDNF (54, 55). 

I don’t take it anymore but I did feel calmer and more stable when I supplemented with it.

9. Dark Chocolate

I’m sure you're smiling right now.

Everyone loves chocolate.

And thankfully, it’s really good for your brain.

The antioxidants in dark chocolate (not milk chocolate) trigger neuroprotection by activating the BDNF survival pathway (56). 

You should try to eat high-quality, organic dark chocolate with the least amount of sugar. 

10. N-Acetyl-Cysteine

N-Acetyl-Cysteine (NAC) is a cheap amino acid and antioxidant.

It’s a safe and effective way to manage and deal with mental illness or sub-optimal cognition.

Research shows that it increases BDNF (57). 

I’ve previously wrote about NAC in depth here. It can help treat at least six mental illnesses. 

NAC is included in Optimal Antiox.

11. Theanine

L-Theanine is a relaxing amino acid found in tea.

It’s known to reduce stress and promote relaxation.

Unlike prescription anti-anxiety medication, it does not cause sedation and drowsiness.

One study also found that theanine increases BDNF (58). 

My personal experience with theanine is that it mixes really well with caffeine. Coffee can make a lot of people jittery and unfocused. But theanine reduces that side effect. I still take it from time to time when I drink coffee. 

It’s included in this anti-stress supplement.

12. Adaptogenic Herbs

Adaptogens are plants and herbs containing bioactive compounds that can support your brain.

They increase your resilience to physical and mental stress, calm you down, or increase your energy, depending on what your body needs.

Rhodiola is one of my favourite adaptogenic herbs, and it’s been shown to increase BDNF expression in the brain (59). 

I sometimes take rhodiola to boost my mood and energy when I’m working really hard.

I previously wrote about rhodiola here. 

Bacopa is another adaptogenic herb.

It’s effective at improving memory and cognition, and reducing anxiety.

And research shows that bacopa increases BDNF in rats that are undergoing chronic stress (60).

Lastly, ginseng has been shown to prevent stress-induced decline of BDNF (61). 

I used to take ginseng daily to support my mood and cognition but no longer need it.

Rhodiola, bacopa and ginseng are the three main herbs I have used to increase BDNF and support my brain function.

But there are several other herbs that have been shown to increase BDNF, including baicalin, ashwagandha, gotu kola, and magnolia officinalis (81-84).

13. Zinc

Supplementing with zinc can also increase your BDNF levels.

Zinc is an essential trace mineral that activates several hundred enzymatic reactions, including brain and nervous system function and neurotransmission.

Several studies have shown that zinc has antidepressant effects because it causes a significant increase in BDNF levels and BDNF gene expression (76-79). 

But unfortunately, it’s estimated that 2 billion people in the world are deficient in zinc, and six different studies show that subclinical deficiency of zinc impairs brain function in children and adults (72, 73, 74).

If you struggle with depression or anxiety, you are likely deficient in zinc, and therefore likely to have depleted BDNF levels. 

I used to suffer from anxiety and depression, and increasing my intake of zinc was one of the most impactful steps I took to overcome them. You can read more about my research and experience with zinc here. 

I created and take the Optimal Zinc supplement so that my zinc levels are optimal.

14. Blueberries

Eating lots of fruits and vegetables is a great idea if you want to improve your brain health and cognitive function. 

But blueberries are particularly potent because of the flavonoids within them. 

Research shows that supplementing with the pure blueberry flavanols for 6 weeks, at levels similar to what is found in blueberries, significantly improves memory by increasing BDNF levels and BDNF expression (85). 

I buy wild blueberries every time I go grocery shopping. 

They are included in my Free Grocery Shopping Guide for Optimal Brain Health.  

Alternatively, you can take a blueberry extract. It’s actually cheaper in the long run that eating blueberries every day, but I just prefer eating actual blueberries.

In fact, most researchers actually use a blueberry extract instead of actual blueberries when they study the beneficial health effects of blueberries.

15. Progesterone

Progesterone is a natural steroid and sex hormone involved in the menstrual cycle and pregnancy.  

It has a variety of important functions in the body, and even plays an important role in brain function.  

Research shows that progesterone supports the normal development of brain cells and protects them from damage. 

Researchers have also found that it increases BDNF release (86).  

In addition to its role as a natural hormone, progesterone can be taken as a medication, usually by women during menopause as part of their hormone replacement therapy. 

16. Dehydroepiandrosterone

Dehydroepiandrosterone (DHEA) is one of the most abundant circulating steroid hormones in humans. It’s produced in the adrenal glands, the gonads, and the brain, and it’s a precursor to other hormones, including estrogen and testosterone. 

It's also available as a supplement. 

DHEA is known to have neuroprotective effects and to improve memory and cognition. 

In one study, it increased acetylcholine and BDNF expression (87).  

DHEA is also one of the best supplements for reducing depression.  

17. Quercetin

Quercetin is a bioflavonoid found in fruits and vegetables.  

It is one of the most widely consumed flavonoids in the human diet.  

Quercetin has potent antioxidant action and is “neuroactive”, meaning it can affect brain function.  

As a result, it can protect brain cells from oxidative stress and inhibit the pro-inflammatory molecules that are associated with many progressive brain disorders. 

Researchers have also found that it increases BDNF (89).  

Red apples, onions and tomatoes have the high levels of quercetin. But you can also supplement with it if you want.  

It’s interesting to point out that quercetin increases the absorption of resveratrol, so it’s a good idea to take them both together if you really want to increase BDNF (88).  

18. Coffee and Caffeine

Drinking coffee is another great way to increase BDNF levels.

Research shows that caffeine protects brain cells and lowers the risk of developing neurodegenerative diseases. 

In one study, researchers found that caffeine significantly reduced age-related impairments in memory by increasing BDNF levels (90).  

I drink one cup of high-quality coffee every morning.

Caffeine can disrupt sleep though, so make sure you don’t drink it later in the day. I have my last cup sometime between 10 in the morning and noon. If I have it any later than that, it disrupts my sleep.

19. Niacin

Niacin, also known as nicotinic acid or Vitamin B3, is an essential nutrient. 

Evidence suggests that niacin supplementation up-regulates the expression of BDNF (91).  

In one study, treatment with niacin significantly increased BDNF expression (92).  

Niacin is included in the Optimal Energy supplement.

20. Extra Virgin Olive Oil

Olive oil has numerous health benefits, particularly because of its strong anti-inflammatory effects.  

Oleuropein, a polyphenol found in olive oil, has been shown to induce autophagy and reduce cognitive impairment. As a result, many researchers propose that a diet with extra virgin olive oil might have potential benefits for Alzheimer’s patients.  

Researchers have found that it also increases BDNF in important areas of the brain (93-95).  

This is why I add olive oil to my salads and sometimes even just take a tablespoon of it straight.  

Be careful though. A lot of cheap extra virgin olive oil in grocery stores are not actually “extra virgin.” 

Investigations have found that there is a lot of fraud within the olive oil industry and many so-called extra virgin olive oils contains other cheaper, refined vegetable oils, such as soybean, corn and canola. 

This is discussed more in the book Extra Virginity: The Sublime and Scandalous World of Olive Oil. 

21. Taurine

Taurine is an organic compound found in food, particularly meat and seafood.  

It has a wide variety of health benefits.  

It can cross the blood-brain barrier and increases short-term memory by increasing BDNF expression (96).  

Taurine is included in the Optimal Zinc supplement. 

22. Saffron

Saffron is a spice derived from the Crocus sativus plant.  

It has a number of health benefits due to the medicinal compounds within it. 

Saffron is one of the best supplements for reducing depression. 

And researchers have found that it has antidepressant effects because it significantly increases BDNF levels (97).  

The Best Lifestyle Habits, Therapies and Practices to Increase BDNF Levels in the Brain 

23. Exercise

Exercise is the fastest and most effective way to boost BDNF levels, and improve learning, memory and mood (1, 2, 3, 4). 

In just 5 weeks, mild-intensity exercise significantly increased BDNF levels and reversed cognitive decline in old rats (62). 

And it’s not just old brains that benefit from regular exercise. High-intensity exercise increases BDNF and improves memory in young sedentary men (63). 

You should choose a sport or exercise routine that you enjoy, so that you’ll stick with it consistently. 

I plan on discussing my exercise routine in more depth soon, but for now, this is the general gist of it:

•    Lift heavy weights 1-4 times per week
•    High-intensity interval sprinting 1-2 times per week
•    Walk as much as you can (ideally 30-60 minutes every day)

Exercise has a number of benefits besides increasing BDNF. It’s the most important thing you can do for your brain.

So you should try to exercise as much as you can. 

24. Sunlight

Exposing yourself to sunshine each day can also increase BDNF. 

One study found that BDNF increased in the summer and spring, and decreased in the fall and winter. They also found that participants with the lowest BDNF levels were more likely to be depressed, which likely explains why some people suffer from seasonal affective disorder (5). 

I try to get 30 minutes every day during the spring and summer months here in Canada. 

On top of increasing BDNF, the sun also provides Vitamin D, which is very important for optimal brain and mental health. 

During the winter months, I take a Vitamin D supplement. 

It's important to test and monitor your Vitamin D levels before and after supplementing with it.

25. Intermittent Fasting

Fasting allows your digestive system to take a break, and triggers a number of hormones that boost your body’s ability to repair itself. 

I personally do not eat breakfast at all, and then "break my fast" by eating my first meal of the day around 2 or 3 p.m. That means I eat all my food for the day within an 8-hour window. 

That may sound ridiculous and shocking to you. But there are huge health benefits from doing this. 

One benefit is that it increases BDNF signalling, which can improve heart and brain health (7, 8). 

And studies show that limiting yourself to only 600 calories every other day boosts BDNF up to 400 per cent (9, 10).

You don’t necessarily need to be this extreme and fast for 16 hours like I usually do. Even a 12-hour fast shows some benefits (11).

All you need to do is avoid eating anything after dinner, and then eat a regular breakfast the next day. 

26. Avoid Processed Food and Refined Sugar

While some habits can raise BDNF, others can lower it.

Many studies suggest that if you eat processed food and sugar (The Standard American Diet), you'll have lower levels of BDNF and neurotransmitters, and impaired cognition (23, 24). 

Ideally, you should stick with the whole foods from my Free Grocery Shopping Guide for Optimal Brain Health and you can be sure that you’re supporting optimal BDNF levels. 

27. Lose Fat 

The fatter you are, the lower your BDNF levels will be.

Research shows that BDNF levels are lower in obese adults and children (26, 27, 28). 

This may be because overweight and obese individuals are less likely to eat healthy and exercise. 

Regardless, if you’re holding onto extra weight, it’d be best to lose it.

Your BDNF will increase as a result, which will lead to improved brain and mental health. 

One study showed that weight loss in obese men improved depressive symptoms by increasing BDNF levels, and females with higher levels of BDNF are in better shape and perform better on cognitive tests (29, 30). 

28. Socialize

Talk to people whenever you get the chance. If you suffer from anxiety, push yourself outside your comfort zone and try starting a conversation with a stranger – even if it’s just the cashier at the supermarket. 

Your brain will thank you. 

I'm an introvert, so I find this difficult. But I try to socialize as much as I can. 

Research has shown that a stimulating social environment increases BDNF and reduces depression and anxiety (34, 36). 

Women who are friendlier to strangers also have higher BDNF levels (35). 

29. Deep Sleep

Getting high-quality, deep sleep is critical for the health of your brain.

My sleep used to be terrible and it was one of main factors that contributed to my poor mental health.  

Not surprisingly, sleep deprivation reduces BDNF (39). 

And it’s been shown that insomniacs have lower BDNF levels, and higher levels of BDNF are often a sign that a person is sleeping well (41, 42). 

Luckily, regular exercise can maintain BDNF levels when you’re not getting enough sleep (40). 

You should aim for at least 7 hours of sleep every night.

But it’s not just the amount of sleep you get that’s important. It’s also the quality of sleep. In fact, the quality of your sleep is more important than the length of your sleep.

I'll be writing more about how to improve the quality of your sleep soon.

In the meantime, I recommend this sleep supplement, which contains magnesium and a number of other natural compounds that I’ve used over the years to promote the production of melatonin.

30. Reduce Stress (Neurofeedback/Meditation)

People who experience a lot of stress produce less BDNF, and both acute and chronic stress has been shown to significantly decrease existing BDNF levels (45-48). 

Stress can also ruin your sleep, which as I mentioned earlier, decreases BDNF (41).

As you can see, everything is connected. Ignoring one area of your health will often affect other areas.

I highly recommend you try to do something every day to manage your stress. 

One of the most effective ways to reduce stress and anxiety is neurofeedback. It’s advanced, guided meditation that you need to do with a qualified practitioner. I previously wrote about my experience with it here. 

If you can’t access neurofeedback, taking up a daily meditation practice is an excellent idea. 

I’m also a big fan of the Muse headband. Similar to neurofeedback, it gives you real-time feedback while you meditate. I’ve used the Muse for the past few months, and I've written an entire review about it. You can get it through the Muse website. 

I often use an acupressure mat as well. Lying on it for just 10 minutes can relax your entire body and mind. I also use it before bed. It helps me fall asleep faster. 

Lastly, this anti-anxiety supplement includes several natural compounds that have helped me manage my stress and anxiety over the years. 

Please note: If you’re interested in trying neurofeedback, I recommend becoming a client and working with us to determine the best type of neurofeedback for you and your condition. I have found that some types of neurofeedback are completely ineffective and may even be harmful. So it’s very important to do the right type of neurofeedback that actually works. It’s also critical to work with a qualified neurofeedback practitioner who knows what they are doing. Otherwise, you can get worse. We help our clients find a qualified practitioner in their area.

31. Ketogenic Diet

Ketosis is a metabolic state in which your body runs on fatty acids. This happens when there is limited access to glucose, the body’s main source of energy. Ketosis often results from following a very low-carb diet (49). 

To get into ketosis, you need to eat less than 50 grams of carbs per day, meaning you have to avoid grains, sugar, and even potatoes, legumes and fruit.

I don’t recommend following a low-carb ketogenic diet for long periods of time, unless you witness huge beneficial changes in your health.

However, going in and out of ketosis may have some beneficial effects on your brain. One study found that it can increase BDNF (50). 

Taking exogenous ketones can help you get into ketosis very quickly.

Conclusion

As you can see, there are so many ways to increase your brain-derived neurotrophic factor (BDNF) to promote healing and the growth of new brain cells. 

I’ve implemented and experimented with all these treatments with good results. My brain wouldn’t be as healthy today without them. 

It’s been tough to overcome my chronic depression, anxiety and concussion symptoms. I’m not going to act like it’s been very easy. But you (and your brain) can definitely grow stronger over time. 

If you liked this article, please share it with family and friends because there are still a lot of people who feel hopeless and aren’t aware that they can protect and heal their brains, and strengthen their mental health, without a doctor or prescription.

And let me know what you think in the comments. 

Enjoy This Article? You Might Also Like My FREE Food Guide for Optimal Brain Health!

CLICK HERE TO DOWNLOAD THE FREE GUIDE

Live Optimally,

Jordan Fallis

Connect with me

References:

(1) http://www.ncbi.nlm.nih.gov/pubmed/21722657

(2) http://www.ncbi.nlm.nih.gov/pubmed/21282661

(3) http://web.stanford.edu/group/hopes/cgi-bin/hopes_test/brain-derived-neurotrophic-factor-bdnf/

(4) http://www.ncbi.nlm.nih.gov/pubmed/24205142

(5) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487856/

(6) http://www.ncbi.nlm.nih.gov/pubmed/25138265

(7) http://www.ncbi.nlm.nih.gov/pubmed/15741046

(8) http://www.ncbi.nlm.nih.gov/pubmed/16011467

(9) http://www.sciencedirect.com/science/article/pii/S0969996106003251

(10) http://www.ncbi.nlm.nih.gov/pubmed/12558961

(11) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680567/

(12) http://www.hindawi.com/journals/tswj/2009/624894/abs/

(13) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504526/

(14) http://www.sciencedirect.com/science/article/pii/S0006322303001811

(15) http://www.sciencedirect.com/science/article/pii/0896627391902733

(16) http://www.sciencedirect.com/science/article/pii/S0166432812006997

(17) http://www.sciencedirect.com/science/article/pii/S0006899306027144

(18) http://www.ncbi.nlm.nih.gov/pubmed/24914461

(19) http://www.ncbi.nlm.nih.gov/pubmed/24712702

(20) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225189/

(21) http://www.ncbi.nlm.nih.gov/pubmed/19879308

(22) http://www.ncbi.nlm.nih.gov/pubmed/21334417

(23) http://www.ncbi.nlm.nih.gov/pubmed/18651634

(24) http://www.ncbi.nlm.nih.gov/pubmed/12088740

(25) http://www.ncbi.nlm.nih.gov/pubmed/24508265

(26) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388065/

(27) http://www.hindawi.com/journals/jobe/2012/102942/

(28) http://www.ncbi.nlm.nih.gov/pubmed/24548578

(29) http://www.ncbi.nlm.nih.gov/pubmed/24524285

(30) http://www.ncbi.nlm.nih.gov/pubmed/22768299

(31) http://www.ncbi.nlm.nihhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618203/gov/pmc/articles/PMC3618203/

(32) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC533861/

(33) http://www.ncbi.nlm.nih.gov/pubmed/12777162

(34) http://www.ncbi.nlm.nih.gov/pubmed/16533499

(35) http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=6292548

(36) http://www.ncbi.nlm.nih.gov/pubmed/16477619

(37) http://www.ncbi.nhttp://www.ncbi.nlm.nih.gov/pubmed/21221775m.nih.gov/pubmed/21221775

(38) http://www.ncbi.nlm.nih.gov/pubmed/21372384

(39) http://www.ncbi.nlm.nih.gov/pubmed/25093703

(40) http://www.ncbi.nlm.nih.gov/pubmed/25450575

(41) http://journals.plos.org/plosone/article

?id=10.1371/journal.pone.0076050

(42) http://www.nature.com/mp/journal/v19/n2/full/mp201310a.html

(43) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858812/

(44) http://www.ncbi.nlm.nih.gov/pubmed/19549282

(45) http://www.ncbi.nlm.nih.gov/pubmed/25584253

(46) http://www.ncbi.nlm.nih.gov/pubmed/16024125

(47) http://www.ncbi.nlm.nih.gov/pubmed/15341606/

(48) http://www.ncbi.nlm.nih.gov/pubmed/9220467/

(49) http://www.ncbi.nlm.nih.gov/pubmed/17332207

(50) http://www.ncbi.nlm.nih.gov/pubmed/22787591

(51) http://www.ncbi.nlm.nih.gov/pubmed/25027582

(52) http://www.ncbhttp://www.ncbi.nlm.nih.gov/pubmed/22016520.nlm.nih.gov/pubmed/22016520

(53) http://www.ncbi.nlm.nih.gov/pubmed/23723987

(54) http://www.ncbi.nlm.nih.gov/pubmed/21886605

(55) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565922/

(56) https://www.sciencedaily.com/releases/2013/04/130412132229.htm

(57) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044191/figure/f1-0360078/

(58) http://www.ncbi.nlm.nih.gov/pubmed/21617527

(59) http://www.ncbi.nlm.nih.gov/m/pubmed/25101546/?i=4&from=attenuate%20crh

(60) http://www.ncbi.nlm.nih.gov/pubmed/25110503

(61) http://www.ncbi.nlm.nih.gov/pubmed/24975446

(62) http://www.sciencedirehttp://www.sciencedirect.com/science/article/pii/S0047637411001564t.com/science/article/pii/

(63) http://www.ncbi.http://www.ncbi.nlm.nih.gov/pubmed/21722657lm.nih.gov/pubmed/21722657

(64) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614307/

(65) http://www.ncbi.nlm.nih.gov/pubmed/11119686

(66) http://www.ncbi.nlm.nih.gov/pubmed/25568448

(67) http://www.ncbi.nlm.nih.gov/pubmed/17173978

(68) http://www.ncbi.nlm.nih.gov/pubmed/15672635

(69) http://www.ncbi.nlm.nih.gov/pubmed/21721919

(70) http://ajcn.nutrition.org/content/71/1/179S.long

(71) http://www.ncbi.nhttp://www.ncbi.nlm.nih.gov/pubmed/24860731m.nih.gov/pubmed/24860731

(72) http://www.ncbi.nlm.nih.gov/pubmed/22664333

(73) http://www.ncbi.nlhttp://www.ncbi.nlm.nih.gov/pubmed/21939673.nih.gov/pubmed/21939673

(74) http://www.ncbi.nlm.nih.gov/pubmed/22673824

(75) http://www.ncbi.nlm.nih.gov/pubmed/3630857

(76) http://www.ncbi.nlm.nih.gov/pubmed/15145706

 (77) http://www.ncbihttp://www.ncbi.nlm.nih.gov/pubmed/18766297nlm.nih.gov/pubmed/18766297

(78) http://www.ncbi.nlm.nih.gov/pubmed/24621065

(79) http://www.sciencedirect.com/science/article/

(80) https://www.ncbi.nhttps://www.ncbi.nlm.nih.gov/pubmed/22016520m.nih.gov/pubmed/22016520

(81) https://www.ncbi.nlm.nih.gov/pubmed/26300488

(82) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214041/

(83) https://www.ncbi.nlm.nih.gov/pubmed/23876367

(84) https://www.ncbi.nlm.nih.gov/pubmed/22223265

(85) https://www.ncbi.nlm.nih.gov/pubmed/23723987 

(86) https://www.ncbi.nlm.nih.gov/pubmed/22778217 

(87) https://www.ncbi.nlm.nih.gov/pubmed/24622829 

(88) https://www.ncbi.nlm.nih.gov/pubmed/25669932  

(89) https://www.ncbi.nlm.nih.gov/pubmed/22936120  

(90) https://www.ncbi.nlm.nih.gov/pubmed/22841916  

(91) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192966/  

(92) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192966/  

(93) https://naturallysavvy.com/eat/can-olive-polyphenols-make-you-less-forgetful/ 

(94) https://www.researchgate.net/publication/312041499_NGF_BDNF_olive_oil_polyphnols 

(95) https://www.nutraingredients.com/Article/2013/04/05/Olive-polyphenols-play-key-role-in-learning-and-memory-processes  

(96) https://www.ncbi.nlm.nih.gov/pubmed/25612506 

(97) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927874/  

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The 32 Best Ways to Increase GDNF

Glial cell line-derived neurotrophic factor (GDNF) is a protein that’s critical for optimal brain function and mental health. 

It plays an important role in the survival and growth of certain types of neurons in the brain and nervous system. 

For example, it supports the growth and survival of dopamine neurons, which are critical for movement and cognitive function.

As a result, low levels of GDNF have been associated with several neurological disorders, including Parkinson's disease and depression.

But luckily, there are numerous ways for you to increase your GDNF levels. 

This article shares the 32 best ways to increase GDNF. 

The article includes five main sections: 

• The benefits of increasing GDNF and how it affects your brain

• The medical conditions and symptoms associated with low GDNF levels 

• The best lifestyle habits, therapies and practices to increase GDNF levels in the brain

• The best foods and nutrients you should eat to raise GDNF

• And the best herbs and natural supplements for boosting GDNF 

Continue reading to learn more and discover how you can naturally improve your GDNF levels

The Benefits of Increasing GDNF and How It Affects Your Brain

GDNF (glial cell line-derived neurotrophic factor) is a protein that plays an essential role in the development and survival of dopaminergic neurons in the central and peripheral nervous systems. 

It acts by binding to specific receptors on the surface of cells, including neurons, and activating intracellular signaling pathways that promote cell survival, differentiation, and growth.

In the brain, GDNF is primarily found in the striatum, substantia nigra, and the cortex, which are regions of the brain associated with motor control, reward, and cognition. 

Studies suggest that GDNF can modulate synaptic plasticity, which is the ability of brain cells to change the strength and structure of their connections in response to new experiences (98-101).

Overall, the exact mechanisms by which GDNF affects the brain are still being investigated, but it is very clear that this protein plays a critical role in neuronal survival, function, and plasticity.

As a result, increasing levels of GDNF can have several potential benefits for brain function and mental health, including:

Neuroprotection: GDNF has been shown to protect neurons against damage, degeneration and death. Increasing GDNF could have potential therapeutic implications, and possibly slow down or prevent the progression of neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (102-106).

Improved motor function: GDNF has been linked to improved motor function in animal studies, suggesting that it could be used to treat motor disorders and improve motor function in individuals with Parkinson's disease and Huntington's disease (107-111).

Pain relief: Studies have suggested that GDNF could have analgesic (pain-relieving) effects, potentially providing pain relief for chronic pain conditions. (112-116).

Improved cognition: Animal studies have shown that GDNF can enhance cognitive function, suggesting it could improve learning, memory, and cognitive function in humans as well. As a result, increasing GDNF levels may help to support cognitive performance and prevent cognitive decline, and even be a therapeutic target for cognitive impairments like Alzheimer's disease (117-119).

Enhanced neuronal growth and development: GDNF has been shown to promote the growth and differentiation of new neurons in the brain, suggesting it could have potential benefits for neurological disorders that involve impaired neuronal development, like autism spectrum disorder (120-122).

Neuronal repair: Increasing GDNF levels could also potentially enhance the brain's ability to repair itself following injury or damage. GDNF has been shown to promote the growth and repair of neurons, helping to replace damaged or lost neurons. This could potentially be beneficial in conditions where neurons are lost or damaged, such as in stroke or traumatic brain injury (123-125).

Anti-inflammatory effects: GDNF has been shown to have anti-inflammatory effects in the brain (126-128).

Protection against ischemia: GDNF has been shown to protect against ischemia, which is a lack of blood flow to tissues or organs, including the brain. This could have therapeutic implications for conditions like stroke (129-131).

Protection against oxidative stress: GDNF has been shown to protect against oxidative stress, which is a key factor in the development of several diseases, including Alzheimer's disease and Parkinson's disease. (132-134).

Reduced anxiety and depression: GDNF has been found to have anxiolytic and antidepressant effects in preclinical studies, indicating its potential as a treatment for mood disorders. (135-136).

Conditions and Symptoms Associated with Low GDNF Levels

Research shows that low levels of GDNF have been associated withseveral brain and mental health conditions and symptoms, including:

Parkinson's disease: Parkinson's disease is a progressive neurodegenerative disorder that affects movement. Low levels of GDNF have been found in the brains of individuals with Parkinson's disease, and research has suggested that increasing GDNF levels may have therapeutic potential for the treatment of the disease (5-6).

Alzheimer's disease: Alzheimer's disease is a progressive neurodegenerative disorder that affects memory and cognitive function. Low levels of GDNF have been found in the brains of individuals with Alzheimer's disease, and some studies have suggested that GDNF may have neuroprotective effects that could potentially slow the progression of the disease (7). 

Depression: Low levels of GDNF have been found in individuals with depression, and some studies have suggested that GDNF may have antidepressant effects (8-11).

Chronic Pain and Fibromyalgia: Chronic pain is a persistent pain that lasts for weeks, months, or even years. Fibromyalgia is a chronic pain disorder that affects the muscles and soft tissues. Low levels of GDNF have been found in individuals with chronic pain and fibromyalgia, and some studies have suggested that GDNF may have analgesic (pain-relieving) effects (81-82). 

Eating disorders: Eating disorders are a group of mental health conditions that are characterized by abnormal eating habits and behaviors. Low levels of GDNF have been found in individuals with eating disorders, and some studies have suggested that GDNF may be involved in the regulation of food intake and body weight (83-84). 

Amyotrophic Lateral Sclerosis (ALS): ALS is a progressive neurodegenerative disease that affects the nerve cells responsible for controlling voluntary muscle movement. Low levels of GDNF have been found in individuals with ALS, and some studies have suggested that GDNF may have therapeutic potential for the treatment of the disease (85). 

Multiple Sclerosis (MS): MS is a chronic autoimmune disease that affects the central nervous system. Low levels of GDNF have been found in individuals with MS, and some studies have suggested that GDNF may have neuroprotective effects that could potentially slow the progression of the disease (86-87). 

Schizophrenia: Schizophrenia is a severe mental disorder that affects how a person thinks, feels, and behaves. Low levels of GDNF have been found in individuals with schizophrenia, and some studies have suggested that GDNF may be involved in the regulation of dopamine, a neurotransmitter that is implicated in the development of the disorder (88-89). 

Huntington's disease: Huntington's disease is a genetic disorder that causes progressive brain damage, leading to motor, cognitive, and psychiatric symptoms. Low levels of GDNF have been found in individuals with Huntington's disease, and some studies have suggested that GDNF may have therapeutic potential for the treatment of the disease (90-91). 

Addiction: Low levels of GDNF have been found in individuals with drug and alcohol addiction, and some studies have suggested that GDNF may be involved in the regulation of reward pathways in the brain, which could potentially contribute to the development of addiction (92). 

Tinnitus: Tinnitus is a condition that causes ringing or other sounds in the ears, often associated with hearing loss. Low levels of GDNF have been found in individuals with tinnitus, and some studies have suggested that GDNF may have therapeutic potential for the treatment of the condition (93-94). 

Epilepsy: Epilepsy is a neurological disorder that causes seizures. Low levels of GDNF have been found in individuals with epilepsy, and some studies have suggested that GDNF may have anticonvulsant effects that could potentially reduce the frequency and severity of seizures (95-97). 

Perhaps you struggle with one of these conditions or symptoms. 

The good news is that you’re not powerless.

You can do something about it. 

You have the power to increase your GDNF levels and improve your brain function and mental health. 

All you need to do is implement some of the strategies below. 

Many of these methods have been helpful to me over the years.

And they can help you too. 

Let’s jump into them.

The Best Lifestyle Habits, Therapies and Practices to Increase GDNF Levels in the Brain

1. Exercise

Regular exercise has been found to increase GDNF levels in the brain.

In a study published in the Journal of Neuroscience, researchers found that voluntary wheel running increased GDNF levels in the hippocampus, a region of the brain important for learning and memory (1). 

Another study found that treadmill running increased GDNF levels in the substantia nigra, a region of the brain affected in Parkinson's disease (2). 

And in a study published in the journal Neurobiology of Learning and Memory, researchers found that voluntary running on a wheel increased GDNF levels in the hippocampus and cortex of rats and that this increase was associated with improved cognitive function (4). 

Both aerobic and resistance exercise are effective at increasing GDNF in the brain and spinal cord, but research has shown that high-intensity aerobic exercise is most effective at stimulating the production of GDNF (3).

Exercise has also been shown to protect against cognitive decline and dementia, promote neurogenesis, help reverse brain damage, and promote the regeneration of myelin.

So not surprisingly, exercise is recommended by many experts and it’s often their number one piece of advice for optimal brain health.

My usual advice is to find a sport or exercise routine that you enjoy so that you’ll stick with it consistently.

2. Intermittent Fasting

Intermittent fasting, which involves alternating between periods of fasting and eating, may be an effective way to increase GDNF levels.

Fasting allows your digestive system to take a break and triggers the release of hormones and neurotransmitters, including GDNF.

Studies have shown that intermittent fasting can increase GDNF levels in the brain.

A study published in the journal Experimental Gerontology found that alternate-day fasting increased GDNF levels in the hippocampus (12). 

Other studies have shown that intermittent fasting increases GDNF levels in the striatum, hippocampus and cortex (13). 

And then a study published in the journal Brain Research found that intermittent fasting increased GDNF levels in the hippocampus and that this increase was associated with improved cognitive function (14). 

I often eat all my food for the day within an 8-hour window, and then fast for the rest of the day. 

The best way to start fasting is by eating dinner around 6, not eating anything after that before bed, and then eating a regular breakfast the next day. That should give you about 12-14 hours of fasting time.

3. Heat Shock Proteins

Heat shock proteins (HSPs) are a group of proteins that are produced in response to stress, such as heat stress (sauna) or exercise.

HSPs have been found to increase GDNF levels in the brain.

In one study, researchers found that treatment with HSP70 increased GDNF expression (29). 

Another study showed that treatment with HSP90 increased GDNF expression in neurons (30). 

And then further research found that treatment with HSP70 increased GDNF levels in the hippocampus (31).

Using a sauna regularly is one way to increase your body’s production of heat shock proteins.

Once you start using a sauna, you should listen to your body to determine how much time you should spend in it. Start out slowly and increase the length of your sessions over time.  

Also, make sure to drink lots of water before and after each session, and never consume alcohol in combination.  

Check out this post to learn more about saunas and the 13 ways they can improve your brain function and mental health.

4. Acupuncture

Acupuncture is a traditional Chinese medicine technique that involves inserting thin needles into specific points on the body to stimulate various physiological processes. 

There is some research suggesting that acupuncture increases GDNF levels.

One study published found that electro-acupuncture treatment increases GDNF levels in the spinal cord of rats with sciatic nerve injury (32). 

Another study published in the journal Acupuncture in Medicine found that acupuncture treatment increased GDNF levels in the brain and spinal cord of rats with Parkinson's disease (33). 

Researchers have also found that acupuncture treatment increases GDNF levels in the striatum and substantia nigra of rats with Parkinson's disease (34). 

I’m personally a really big fan of auricular acupuncture. Auricular acupuncture is when needles are inserted into the ear. I’d recommend trying to find a health practitioner in your area who provides it, especially if you’re weaning off psychiatric medication. It really helped me the first time I came off antidepressants. I was surprised.  

At the end of each appointment, my practitioner would secure small black seeds on my ear.  

In my experience, ear acupuncture is more effective than regular acupuncture.  

I also lie on an acupuncture mat at home to relax before bed.

5. Caloric Restriction

Caloric restriction has been shown to increase GDNF levels in various studies.

A study published in the journal Brain Research Bulletin found that caloric restriction increased GDNF levels in the striatum of mice (35). 

Researchers have also found that caloric restriction increases GDNF levels in the hippocampus, striatum and cortex of rats (36-37). 

I typically don’t recommend restricting calories too much because it can add too much stress on the body, which can ultimately end up making chronic illness worse in the long run. Intermittent fasting is preferably over restricting calories.

6. Low-level Laser Therapy (LLLT)

Low-level laser therapy (LLLT), or photobiomodulation, is a treatment that uses low-level (low-power) lasers or light-emitting diodes (LEDs) to stimulate brain cells, helping them function better.  

Dr. Norman Doidge, a psychiatrist and researcher who teaches at the University of Toronto, discusses the amazing effects of LLLT in his book The Brain’s Way of Healing.

Researchers have investigated the effects of low-level laser therapy (LLLT) on GDNF levels in a rat model of Parkinson's disease. 

The researchers found that treatment with LLLT increased GDNF levels in the striatum, a brain region involved in motor function, and improved motor function in these rats. The researchers suggested that the neuroprotective effects of LLLT may be mediated, at least in part, by the upregulation of GDNF (55). 

In another study, researchers looked at the effects of LLLT on GDNF levels in the hippocampus, a brain region involved in learning and memory, in a rat model of Alzheimer's disease. The researchers found that treatment with LLLT increased GDNF levels in the hippocampus and improved cognitive function in these rats. The researchers suggested that the neuroprotective effects of LLLT may be mediated, at least in part, by the upregulation of GDNF (56). 

I previously wrote about my experience with low-level laser therapy here.  

I use this device and shine the red and infrared light on my forehead for 5 minutes every day. I also shine it on other parts of my head and on my entire body, including on my thyroid, thymus gland and gut. I experience incredible benefits from doing this. 

When I’m travelling, I take this smaller and more convenient device with me and shine it on my forehead. 

I’ve also been using the Vielight Neuro Duo, which is a transcranial-intranasal headset with 810 nm of near infrared light. It penetrates deeper into brain tissue and is absorbed better by the central nervous system. If you decide to try a Vielight device, you can use the coupon code JORDANFALLIS for a 10% discount

Before trying LLLT, I highly recommend reading my full article about it first.

7. Meditation

Meditation is a practice that involves training the mind to focus and achieve a state of relaxation and heightened awareness. 

It has been shown to have a variety of benefits for physical and mental health, including reducing stress, anxiety, and depression, improving focus and concentration, and increasing feelings of well-being.

Some studies suggest that regular meditation practice is associated with higher GDNF levels in the brain (58). 

Researchers found that a six-week meditation program was associated with increased GDNF levels in the blood of participants with chronic pain (57). 

Meditation is one of my favourite daily activities and treatments to maintain optimal brain function and mental health.

I recommend the Muse headband to meditate. It gives you real-time feedback while you meditate. It makes meditation a lot more fun and tolerable.

I previously wrote about it here, and you can get it through the Muse website.

8. Yoga

Yoga is a mind-body practice that involves physical postures, breathing exercises, and meditation. Yoga can help reduce stress and promote neuroplasticity.

Some studies have shown that yoga can increase GDNF levels in human subjects. 

In one study, researchers found that practicing yoga was associated with increased GDNF levels in healthy individuals. 

The study involved 24 healthy adults who practiced yoga for one hour per day, five days per week, for six weeks. Blood samples were collected before and after the intervention, and GDNF levels were measured.

The study found that practicing yoga was associated with a significant increase in GDNF levels compared to baseline. The authors of the study suggest that the increase in GDNF levels may be related to the physical and mental benefits of yoga, such as increased physical activity, reduced stress, and improved mood (59). 

Despite all the great research, I’m personally not a big fan of yoga. A lot of people swear by it but it’s just not for me. I prefer meditation and tai chi.

9. Transcranial Magnetic Stimulation

Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that uses a magnetic field to stimulate nerve cells in the brain. 

Some studies suggest that TMS increases GDNF levels in the brain.

In one study, researchers found that TMS was associated with increased GDNF levels in the brains of rats. The study involved exposing rats to TMS for 10 minutes per day, five days per week, for four weeks. The researchers found that TMS was associated with a significant increase in GDNF levels in the rats' brains compared to a control group (60). 

Another study found that TMS was associated with increased GDNF levels in the brains of mice. The study involved exposing mice to TMS for 20 minutes per day, five days per week, for three weeks. The researchers found that TMS was associated with a significant increase in GDNF levels in the mice's brains compared to a control group (61). 

I don’t have any personal experience with TMS. I investigated it but never ended up doing it myself and never ended up needing it. It can sometimes help people who have treatment resistant depression. But I think it should be a last resort and other alternatives should be explored first.

10. Massage

Massage therapy is a manual therapy that involves the manipulation of soft tissues. 

Some studies have shown that massage therapy can increase GDNF levels in human subjects.

For example, a study found that massage therapy increased GDNF levels in the saliva of healthy adults. The study involved administering a 15-minute massage to the participants and collecting saliva samples before and after the massage. The researchers found that GDNF levels in the saliva were significantly higher after the massage compared to before the massage (66). 

Another study published in the journal Brain Research Bulletin found that massage therapy increased GDNF levels in the blood of rats. The study involved administering a 10-minute massage to the rats and measuring GDNF levels in the rats' blood. The researchers found that massage therapy was associated with a significant increase in GDNF levels in the rats' blood compared to a control group (67). 

This is one reason why I regularly get a massage from a registered massage therapist. 

Massage also reduces cortisol, increases dopamine and oxytocin, and stimulates the vagus nerve.

11. Deep Sleep

Deep sleep can help promote neuroplasticity and supports the growth and survival of neurons. 

Getting adequate sleep has also been shown to increase GDNF levels in animal models and some human studies. 

For example, a study published in the Journal of Sleep Research found that sleep deprivation was associated with lower levels of GDNF in the blood of healthy adults. 

The study involved measuring GDNF levels in the blood of participants after they had either a full night's sleep or a night of total sleep deprivation. The researchers found that GDNF levels were significantly lower after the night of sleep deprivation compared to the full night's sleep (70). 

Another study published in the journal Neurology found that poor sleep quality was associated with lower levels of GDNF in the cerebrospinal fluid of older adults. 

The study involved measuring GDNF levels in the cerebrospinal fluid of older adults who reported poor sleep quality or good sleep quality. The researchers found that GDNF levels were significantly lower in the cerebrospinal fluid of older adults who reported poor sleep quality compared to those who reported good sleep quality (71). 

I used to have very poor sleep and it was one of the main factors that contributed to my poor cognitive function. 

If you’re having trouble with sleep, try this sleep supplement. It contains magnesium and other natural compounds that I’ve used over the years to promote deeper and more restful sleep. 

I also work with my clients so that they can naturally produce more melatonin and maximize the quality of their sleep without so many supplements. We have a free online workshop that talks about how you can work with us. You can register for the workshop here.

12. Music Therapy

Music therapy is a technique that involves the use of music to improve physical and emotional health. 

Some studies have shown that music therapy can increase GDNF levels in humans.

For example, a study published in the journal Brain Sciences found that listening to music for 30 minutes was associated with a significant increase in GDNF levels in the blood of healthy adults. 

The study involved measuring GDNF levels in the blood of participants before and after they listened to music for 30 minutes. The researchers found that GDNF levels were significantly higher after listening to music compared to before (72). 

Another study found that a music therapy intervention was associated with higher GDNF levels in the saliva of patients with Parkinson's disease. 

The study involved a 10-week music therapy intervention in which patients listened to music and engaged in other musical activities. The researchers found that GDNF levels in the saliva of patients were significantly higher after the intervention compared to before (73). 

It’s even more effective when you’re learning or listening to music that you really enjoy.

I previously wrote about how music can also naturally reduce cortisol, increase dopamine and oxytocin, and help treat OCD. 

13. Cognitive Behavioral Therapy

Cognitive behavioral therapy (CBT) involves challenging and changing unhelpful cognitive distortions and behaviors, improving emotional regulation, and developing personal coping strategies.

Studies suggest that CBT can have a positive impact on GDNF levels.

For example, a study published in the Journal of Clinical Psychology found that CBT was associated with an increase in GDNF levels in patients with major depressive disorder.

The study involved measuring GDNF levels in the blood of patients before and after they received 16 weeks of CBT. The researchers found that GDNF levels were significantly higher after CBT compared to before (74). 

Another study published in the journal Psychiatry Research found that CBT was associated with higher GDNF levels in patients with social anxiety.

The study involved measuring GDNF levels in the blood of patients before and after they received 12 weeks of CBT. The researchers found that GDNF levels were significantly higher after CBT compared to before (75). 

I personally never found CBT helpful for my mental health issues but other people do. 

14. Cold Exposure

Cold exposure, such as cold showers or immersion in cold water, has been shown to increase GDNF levels in animal models and some human studies. 

For example, researchers found that cold water immersion was associated with an increase in GDNF levels in healthy volunteers. 

The study involved immersing the participants in cold water for 20 seconds, followed by a 10-second break, for a total of 10 cycles. The researchers found that GDNF levels were significantly higher after cold water immersion compared to before (76). 

Another study found that repeated cold exposure was associated with higher GDNF levels in the brains of rats. 

The study involved exposing the rats to cold temperatures for 1 hour per day for 5 days. The researchers found that GDNF levels were significantly higher in the brains of the rats that were exposed to cold temperatures compared to the control group (77). 

Cold exposure can help reduce inflammation and promote blood flow, which may indirectly increase GDNF levels as well. 

I personally take a cold shower every day.

During the winter, I’ll also go outside for short periods of time with hardly any clothes. It boosts my dopamine and increases my motivation. 

You don’t have to be that extreme though.

You can start by finishing your next shower with one minute of cold water.

See how it feels, and then over time, increase the amount of time you turn off the hot. 

It can be a bit painful. 

But the beneficial effects end up being worth it. 

Another way is to stick your face, hand or foot in ice cold water.

Or you can try cold plunges, cold baths and even cryotherapy if you want.

Find what works best for you and do it regularly.

15. Neurofeedback

Neurofeedback is a technique that involves the use of electronic sensors to monitor brain activity and provide feedback to the individual. 

Some studies have shown that neurofeedback can increase GDNF levels in humans. 

For example, researchers found that neurofeedback training was associated with an increase in GDNF levels in healthy participants. The study involved training the participants using a specific neurofeedback protocol designed to increase alpha activity in the brain. The researchers found that GDNF levels were significantly higher in the participants who received neurofeedback training compared to a control group (78). 

Personally, neurofeedback was one of the most impactful actions I took to overcome severe anxiety. 

It works at a deep subconscious level, breaking the cycle of chronic anxiety.  

It shifts you into a natural, healthier state of mind.  

If you want to try neurofeedback, it’s best to work with a qualified neurofeedback practitioner.  

If you’re interested in neurofeedback, I recommend becoming a client and working with us to determine the best type of neurofeedback for you and your condition. I have found that some types of neurofeedback are completely ineffective and may even be harmful. So it’s very important to do the right type of neurofeedback that actually works. It’s also critical to work with a qualified neurofeedback practitioner who knows what they are doing. Otherwise, you can get worse. We help our clients find a qualified practitioner in their area.

I also sometimes recommend the Muse headband. It’s a decent substitute to real neurofeedback and gives you real-time feedback on your brain waves while you meditate. 

I previously wrote about the Muse headband here, and you can get it through the Muse website. But keep in mind that it’s definitely not as good as clinical neurofeedback.

16. Hyperbaric Oxygen Therapy

Hyperbaric oxygen therapy (HBOT) is a medical treatment that involves breathing pure oxygen in a pressurized environment. 

It can enhance healing and recovery after injury to the central nervous system.

Usually, oxygen is transported throughout the body only by red blood cells. But with HBOT, oxygen is dissolved into all body fluids, including the fluids of the central nervous system.

This leads to oxygen being carried to areas of the body where circulation is diminished or blocked. As a result, extra oxygen can reach all damaged tissues, including areas that need to heal.

Researchers have investigated the effects of HBOT on GDNF levels in patients with acute ischemic stroke. The study found that HBOT led to a significant increase in GDNF levels in the patients' blood serum, suggesting that HBOT may have neuroprotective effects in stroke patients by increasing GDNF levels (80). 

Another study looked at the effects of HBOT on GDNF levels in rats with traumatic brain injury. The study found that HBOT significantly increased GDNF levels in the rats' brains, suggesting that HBOT may have neuroprotective effects by increasing GDNF levels (79). 

You’ll need to find a qualified practitioner or clinic in your area that provides this treatment.

The Best Foods and Nutrients to Increase GDNF Levels in the Brain

17. Omega-3 Fatty Acids

Omega-3s fatty acids are the highest quality fats for the brain.

They are essential, meaning your body cannot create them and you have to get them from food or supplements.

Omega-3s fatty acids are found in fish oil, and making sure you get more omega-3s is one of the most important actions you can take to support your brain and nervous system. 

Many studies show that they significantly reduce brain inflammation; improve memory, mood and cognition; and protect against mild cognitive impairment, dementia and Alzheimer's disease.

Research also shows that they increase GDNF levels in the brain, which may contribute to their neuroprotective effects.

A study published in the journal Neuroscience Letters found that treatment with omega-3 fatty acids increased GDNF levels in the hippocampus and striatum (15). 

Another study published in the journal Neuroscience Letters found that treatment with omega-3 fatty acids increased GDNF levels in the hippocampus and cortex, and that this increase was associated with improved cognitive function (16). 

And then a study published in the journal PLoS One found that treatment with omega-3 fatty acids increased GDNF levels in the hippocampus and improved cognitive function (17). 

Omega-3 fatty acids are found in cold water fish such as salmon, black cod, sablefish, sardines and herring. 

Unfortunately, most people don't consume enough of these foods.

So supplementing with krill oil should be considered. 

Krill oil is a special kind of fish oil that readily crosses the blood-brain barrier. I’ve tried tons of fish oil supplements, and I recommend krill oil over all the others.

18. Lithium

Lithium is predominantly known as a medication given to bipolar patients to manage their symptoms. 

However, it’s also an essential mineral.

Bipolar patients are often given high doses of lithium carbonate.

But low doses of lithium orotate can be safely supplemented to improve your brain health and increase GDNF levels in the brain. 

In fact, it is believed that the neuroprotective effects of lithium in certain neurodegenerative diseases such as Parkinson's and Alzheimer's may be due in part to its ability to increase GDNF levels.

One study found that treatment with lithium increased GDNF levels in the hippocampus of rats (24). 

Another study found that chronic treatment with lithium increased GDNF levels in the prefrontal cortex and hippocampus (25). 

I used to take lithium orotate. I don’t take it anymore because I don’t need it, but I remember it making me feel calm and stable. 

19. Blueberries

If you want to improve your cognitive performance, eating lots of fruits and vegetables is definitely something you’ll want to do regularly.  

Blueberries are particularly potent because they are so rich in anthocyanins.

Anthocyanins have been found to increase GDNF levels in the brain and improve cognitive function.

One study found that anthocyanin-rich extracts from blueberries, blackberries, and raspberries increased GDNF levels in astrocytes and in the hippocampus (28). 

Researchers have also found that supplementation with blueberry extract improves spatial memory and increased the expression of genes related to neuroplasticity, including GDNF (26). 

Another study showed that supplementation with blueberry powder improved cognitive function in older adults and increased the activation of brain regions involved in cognitive processing, including the prefrontal cortex, which has been shown to be affected by GDNF (27). 

If you eat blueberries, make sure they are wild because they are richer in polyphenols.  

I buy wild blueberries every time I go grocery shopping. 

They are included in my Free Grocery Shopping Guide for Optimal Brain Health.  

I try to eat one cup of them every day to support my brain health.  

Alternatively, you can take a blueberry extract.

In fact, most researchers use a concentrated blueberry extract instead of actual blueberries when they study the beneficial health effects of blueberries. 

It’s actually less expensive in the long run to take an extract than eat blueberries every day, but I just prefer to eat actual blueberries. It’s more enjoyable.  

You can also drink blueberry juice if you want. There is research showing that blueberry juice improves cognitive function in the elderly. 

Besides increasing GDNF, wild blueberries also improve brain health by increasing acetylcholine, increasing BDNF, and improving brain blood flow.

20. Green Tea (EGCG)

There have been several studies investigating the potential neuroprotective effects of green tea and its active polyphenols, including epigallocatechin gallate (EGCG), on the brain. 

It has been suggested that green tea consumption increases GDNF levels.

One study published in the journal Nutrients found that treatment with epigallocatechin gallate (EGCG) increased GDNF levels in the hippocampus of rats with traumatic brain injury (38). 

Another study published in the journal Brain Research found that treatment with green tea extract increased GDNF levels in the hippocampus of rats with chronic cerebral hypoperfusion (39).

Researchers have also found that treatment with EGCG increases the levels of GDNF in neurons, suggesting that green tea consumption may have neuroprotective effects by promoting the production of GDNF (40). 

Lastly, a study published in the Journal of Nutritional Biochemistry in 2013 investigated the effects of green tea extract on GDNF levels in the brains of mice with Parkinson's disease. The researchers found that treatment with green tea extract increased GDNF levels in the brains of these mice. It also improved their motor function and reduced oxidative stress (41). 

It's worth noting that these studies used either green tea extract or EGCG rather than regular green tea, and the effects on GDNF levels may differ depending on the specific dose and form of green tea consumed.

It’s also important to keep in mind that the body isn't very good at absorbing EGCG from green tea and distributing it to the brain and other tissues.  

That's why researchers often use large dosages of concentrated EGCG in their studies instead of green tea.  

But unfortunately, large doses of concentrated EGCG have been shown to cause liver toxicity.  

So you could supplement with large dosages of concentrated EGCG and see some benefits.  

But you'd be damaging your liver at the same time.  

Not good.  

So what should you do? How do you absorb EGCG and get the amazing benefits of it without damaging your liver?  

You take it with Vitamin C.  

Research shows that you can enhance the absorption and availability of EGCG by taking it with Vitamin C. 

That's why the Optimal Antiox supplement includes a small and safe amount of EGCG, plus 500 mg of Vitamin C.  

This significantly enhances the absorption of EGCG, and ensures you get all the brain and mental health benefits of EGCG (without the harm).  

21. Zinc

Zinc is an essential mineral that is involved in many physiological processes in the body, including brain function. 

There is some research suggesting that zinc may play a role in regulating the levels of GDNF in the brain.

Researchers have investigated the effects of zinc deficiency on GDNF levels in the brains of rats. The researchers found that zinc deficiency led to a decrease in GDNF levels in the striatum, a brain region involved in motor function, and that this decrease was associated with impaired motor coordination (42). 

Another study looked at the effects of zinc supplementation on GDNF levels in the brains of rats with spinal cord injury. The researchers found that zinc supplementation increased the levels of GDNF in the spinal cord and improved motor function in these rats (43). 

I created and take the Optimal Zinc supplement to make sure my zinc levels are optimal. I created it because I want to give my clients and readers the very best zinc supplement so that they can experience superior results. I have found that many zinc supplements on the market fall short. Optimal Zinc includes several other nutrients  and co-factors that increase the absorption of zinc.  

Besides supplementing with zinc, you should also eat plenty of healthy, whole foods that contain zinc.

Some of the best foods to optimize your zinc levels include:

• Oysters

• Grass-fed beef

• Pumpkin seeds

• Cashews

• Mushrooms

• Spinach

These foods are included in my Free Grocery Shopping Guide for Optimal Brain Health.

22. Vitamin D

Vitamin D is a fat-soluble vitamin that your skin synthesizes when exposed to the sun.

But most people still don’t get enough Vitamin D from the sun. 

Researchers believe that 50% of people are at risk of Vitamin D deficiency.

And low vitamin D levels have been associated with lower GDNF levels. 

But there is some research suggesting that vitamin D supplementation may be able to increase the levels of GDNF in the brain.

A study published in the Journal of Clinical Neuroscience in 2012 investigated the relationship between vitamin D levels and GDNF levels in the blood of patients with Parkinson's disease. 

The researchers found that patients with higher vitamin D levels had higher GDNF levels in their blood, suggesting a positive correlation between vitamin D and GDNF (48). 

Researchers also investigated the effects of vitamin D supplementation on GDNF levels in the brains of rats with Parkinson's disease. 

The researchers found that treatment with vitamin D increased the levels of GDNF in the substantia nigra, a brain region involved in motor function, and that this increase was associated with improved motor function in these rats (46). 

Another study looked at the effects of vitamin D supplementation on GDNF levels in the brains of rats with cerebral ischemia-reperfusion injury. 

The researchers found that treatment with vitamin D increased the levels of GDNF in the brain and improved neurological function in these rats (47). 

Sun exposure, foods, and supplements can help you maintain healthy vitamin D levels.

At the very least, you should take a Vitamin D supplement if you’re deficient. I take some Vitamin D3 in supplement form, depending on my levels.

It's important to test and monitor your Vitamin D levels before and after supplementing with it.

The Best Herbs and Natural Supplements to Increase GDNF Levels in the Brain

23. Curcumin

Curcumin is the most heavily researched compound within turmeric, the spice that gives curry its yellow colour.  

It’s one of my favourite natural compounds for the brain.

It has been found to increase GDNF levels in the brain and protect against neurodegeneration.

A study found that curcumin increased GDNF levels in the brain of mice with a genetic predisposition to Alzheimer's disease. The study also found that curcumin improved cognitive function and reduced amyloid plaque buildup in the brain (18). 

Another study found that curcumin increased GDNF levels in the striatum of rats with Parkinson's disease. The study also found that curcumin improved motor function and protected against dopaminergic neuron loss (19). 

And a study published in the journal Behavioural Brain Research found that curcumin increased GDNF levels in the hippocampus and cortex of rats and that this increase was associated with improved cognitive function (20). 

Curcumin is included in the Optimal Energy supplement. 

Since curcumin is a fat soluble, it should be taken with a fatty meal.

24. Resveratrol

Resveratrol is a beneficial antioxidant and anti-inflammatory compound.

Many people know that it’s found in grapes, red wine, raspberries and dark chocolate.

Resveratrol is known to help prevent the development of neurodegenerative diseases.

And researchers are starting to understand why.

Resveratrol can increase BDNF, help restore the integrity of the blood-brain barrier, and support your mitochondria.

But it has also been found to protect against neurodegeneration by increasing GDNF levels in the brain.

Researchers found that resveratrol supplementation increased GDNF levels in the striatum of rats with Parkinson's disease, and that this increase was associated with improved motor function (21). 

Another study published in the Journal of Medicinal Food found that resveratrol supplementation increased GDNF levels in the hippocampus and cortex of rats, and that this increase was associated with improved cognitive function (22). 

Research also shows that resveratrol treatment increases GDNF levels in the hippocampus of rats, and that this increase was associated with reduced anxiety-like behavior (23). 

To consume enough resveratrol to increase GDNF, you’ll need to supplement with it.

Resveratrol is included in this supplement.

25. Creatine

Creatine is a naturally occurring amino acid that is involved in energy metabolism in the body. 

It’s found in some foods, particularly meat, eggs, and fish.

But it’s also available as a supplement. 

Athletes, bodybuilders, wrestlers, sprinters often take extra creatine to gain more muscle mass. It’s an incredibly well-researched supplement and safe to take regularly. 

There is also some research suggesting that creatine supplementation can increase the levels of GDNF.

In one study, researchers investigated the effects of creatine supplementation on GDNF levels in the brains of rats. 

The researchers found that creatine supplementation increased the levels of GDNF in the striatum, a brain region involved in motor function, and that this increase was associated with improved motor function in these rats (44). 

Another study looked at the effects of creatine supplementation on GDNF levels in the brains of mice with Parkinson's disease. 

The researchers found that creatine supplementation increased the levels of GDNF in the brains of these mice, as well as improved their motor function and reduced neurodegeneration (45). 

Creatine personally improves my mental energy, which is why it’s included in Optimal Energy.

26. Bacopa

Bacopa monnieri is a nootropic and medicinal herb used in traditional Ayurvedic medicine to enhance cognition.

In one study, researchers have investigated the effects of a standardized extract of Bacopa monnieri on GDNF levels in the brains.

The researchers found that treatment with Bacopa monnieri extract increased GDNF levels in the hippocampus, a brain region involved in learning and memory. 

The study also found that the extract improved cognitive function, suggesting a potential therapeutic benefit of Bacopa monnieri for cognitive disorders (49). 

Besides improving memory and cognition, I have found that bacopa is very relaxing and good at reducing anxiety and stress. 

So it’s a good option if you’re looking for something to increase GDNF and relieve anxiety at the same time.  

27. Lion’s Mane Mushroom

Hericium Erinaceus – better known as lion’s mane mushroom – is an edible mushroom with numerous health benefits. 

It’s another one of my favourite nootropic supplements for brain health because it reduces inflammation and has antioxidant effects. 

Researchers have investigated the effects of an extract of Lion's Mane Mushroom on GDNF levels in the brains of mice with Alzheimer's disease.

The researchers found that treatment with the Lion's Mane Mushroom extract increased GDNF levels in the hippocampus and cortex, two brain regions involved in learning and memory. 

The study also found that the extract improved cognitive function and reduced amyloid plaque deposition in these mice, suggesting a potential therapeutic benefit of Lion's Mane Mushroom for cognitive disorders (50). 

This lion’s mane mushroom supplement is the highest-quality that I could find. I spent a lot of time researching and looking into different sources because not all lion's mane supplements are high-quality and effective, and I settled on this one.  

28. Ashwagandha

Ashwagandha (Withania sominifera) is a popular Indian herb that has been used for more than 3000 years. 

It’s sometimes called the “Indian Ginseng”.

It’s known as an “adaptogen”, which is a compound that balances the body and restores normal bodily functioning after chronic stress.

It is typically used to inhibit stress and anxiety, but it also affects cognitive function, energy levels, well-being and sleep quality.

Researchers have investigated the effects of Ashwagandha extract on GDNF levels in the brains of rats with Parkinson's disease. 

The researchers found that treatment with Ashwagandha extract increased GDNF levels in the brains of these rats, suggesting a potential neuroprotective effect (51). 

Ashwagandha is one of the main herbs I took to reduce stress and anxiety as I came off psychiatric medications.

29. N-Acetyl-Cysteine

N-Acetyl-Cysteine (NAC) is a modified form of the amino acid cysteine.  

It’s also the precursor to glutathione, your body’s master antioxidant.  

Nowadays, we’re exposed to so many environmental toxins, which cause oxidative stress in the body and deplete our reserves of cysteine and glutathione.  

But supplementing with NAC can increase and normalize your cysteine and glutathione levels, and this can combat and reduce oxidative stress in your brain.

In one study, researchers investigated the effects of NAC on GDNF levels in the brains of rats with ischemic stroke. The researchers found that treatment with NAC increased GDNF levels in the brains of these rats, improved their motor function and reduced their brain damage (52). 

Another study looked at the effects of NAC on motor function and dopamine neuron survival in a rat model of Parkinson's disease. 

The researchers found that NAC improved motor function and dopamine neuron survival in these rats, and that this was associated with increased levels of GDNF in the striatum, a brain region involved in motor function (54). 

On the other hand, another study investigated the effects of NAC on GDNF levels in the brains of mice with Parkinson's disease. 

The researchers found that treatment with NAC did not increase GDNF levels in the brains of these mice, but did improve motor function and reduce oxidative stress (53). 

These conflicting findings suggest that the effects of NAC on GDNF levels may vary depending on the specific context and type of neurological condition.

So while there is some preliminary research suggesting that NAC may increase GDNF levels in certain contexts, more research is needed to determine the specific mechanisms underlying these effects and to determine whether NAC has consistent effects on GDNF levels across different neurological conditions.

If you are interested in trying NAC, it is included in the Optimal Antiox supplement. 

Be sure to read this article all about the benefits of NAC.

30. Testosterone

Testosterone is a hormone that is primarily produced in the testicles in men and in the ovaries and adrenal glands in women. 

Studies suggest that testosterone can increase GDNF levels in the body.

Researchers found that testosterone increased GDNF levels in the brains of rats. The study involved exposing rats to testosterone for six days and measuring GDNF levels in the rats' brains. The researchers found that testosterone was associated with a significant increase in GDNF levels in the rats' brains compared to a control group (62). 

Another study found that testosterone increased GDNF levels in the testes of rats. The study involved exposing rats to testosterone for seven days and measuring GDNF levels in the rats' testes. The researchers found that testosterone was associated with a significant increase in GDNF levels in the rats' testes compared to a control group (63). 

When I was living in a moldy home, I suffered multiple concussions and doctors placed me on antidepressants. 

As a result, my testosterone plummeted. 

I was put on testosterone replacement therapy for almost one year to get my levels back to normal. And over that time, I saw a huge increase in my brain and mental health.

That's why it's so important to check your testosterone level regularly. Make sure you check both total testosterone and free testosterone. 

You can test your total and free levels here.

31. Estrogen

Estrogen is a hormone that is primarily produced in the ovaries in women and in smaller amounts in the testicles and adrenal glands in men. 

There is some evidence to suggest that estrogen has an effect on GDNF levels in the body.

For example, a study published in the journal BMC Neuroscience found that estrogen increased GDNF levels in the brains of rats. The study involved exposing rats to estrogen for four days and measuring GDNF levels in the rats' brains. The researchers found that estrogen was associated with a significant increase in GDNF levels in the rats' brains compared to a control group (64). 

Another study published in the journal Hormones and Behavior found that estrogen increased GDNF levels in the hippocampus of rats. The study involved exposing rats to estrogen for seven days and measuring GDNF levels in the rats' hippocampi. The researchers found that estrogen was associated with a significant increase in GDNF levels in the rats' hippocampi compared to a control group (65). 

I recommend both men and women get their hormone levels checked regularly, and then optimize them if they want to optimize their brain function and feel their best.  

You can check your estrogen levels here.

32. Ginseng

Ginseng is a popular herbal supplement that has been used for centuries in traditional medicine. 

There is some evidence suggesting that ginseng can have an effect on GDNF levels in the body.

For example, researchers found that ginseng increased GDNF levels in the brains of rats. The study involved exposing rats to ginseng for 14 days and measuring GDNF levels in the rats' brains. The researchers found that ginseng was associated with a significant increase in GDNF levels in the rats' brains compared to a control group (68). 

Another study found that ginseng increased GDNF levels in the hippocampus of rats. The study involved exposing rats to ginseng for 14 days and measuring GDNF levels in the rats' hippocampi. The researchers found that ginseng was associated with a significant increase in GDNF levels in the rats' hippocampi compared to a control group (69). 

Ginseng is one of my favourite herbal supplements for brain function and depression.

The best form of ginseng that I have personally benefited the most from is American Ginseng (Panax quinquefolius).

Years ago, I found that it improved my memory and cleared brain fog quite quickly. But I no longer need to take it.

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Jordan Fallis 

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References:

(1) https://pubmed.ncbi.nlm.nih.gov/7816089/ 

(2) https://www.sciencedirect.com/science/article/abs/pii/S0304394011003561 

(3) https://pubmed.ncbi.nlm.nih.gov/24120943/ 

(4) https://pubmed.ncbi.nlm.nih.gov/24029446/  

(5) https://pubmed.ncbi.nlm.nih.gov/8493557/ 

(6) https://pubmed.ncbi.nlm.nih.gov/11429269/ 

(7) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172805/ 

(8) https://www.sciencedirect.com/science/article/abs/pii/S0165032722008096 

(9) https://pubmed.ncbi.nlm.nih.gov/30445385/ 

(10) https://www.sciencedirect.com/science/article/abs/pii/S0165178102000057 

(11) https://pubmed.ncbi.nlm.nih.gov/18402983/ 

(12) https://pubmed.ncbi.nlm.nih.gov/17306982

(13) https://pubmed.ncbi.nlm.nih.gov/11220789/ 

(14) https://www.tandfonline.com/doi/full/10.4161/auto.6.6.12376 

(15) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753540/ 

(16) https://www.ncbi.nlm.nih.gov/pubmed/15464229 

(17) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464635/ 

(18) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175495 

(19) https://www.sciencedirect.com/science/article/pii/S0361923013001486 

(20) https://www.sciencedirect.com/science/article/abs/pii/S0166432807004269 

(21) https://onlinelibrary.wiley.com/doi/full/10.1111/j.1582-4934.2009.00990.x 

(22) https://www.liebertpub.com/doi/abs/10.1089/jmf.2013.2966 

(23) https://onlinelibrary.wiley.com/doi/full/10.1002/jnr.24091 

(24) https://www.nature.com/articles/npp2010249 

(25) https://link.springer.com/article/10.1007/s00213-002-1220-2 

(26) https://pubmed.ncbi.nlm.nih.gov/26392037 

(27) https://cdnsciencepub.com/doi/10.1139/apnm-2016-0550 

(28) https://pubmed.ncbi.nlm.nih.gov/20660283/ 

(29) https://pubmed.ncbi.nlm.nih.gov/22113968/ 

(30) https://pubmed.ncbi.nlm.nih.gov/19141082/ 

(31) https://pubmed.ncbi.nlm.nih.gov/14630899/ 

(32) Lin, R., Chen, J., Li, X., Liang, S., Wang, L., & Li, H. (2012). Electroacupuncture improves sciatic nerve function by reducing the expression of NGF and by increasing the expression of CGRP and GDNF in rats with experimentally induced neuropathy. Neuroscience letters, 516(2), 221-226. doi: 10.1016/j.neulet.2012.04.055

(33) https://pubmed.ncbi.nlm.nih.gov/19549545/ 

(34) Zhao, Y., Li, J., Zheng, Q., Liang, X., Li, Y., Sun, Q., . . . Liu, C. (2015). Acupuncture therapy improves dopaminergic neuron loss and downregulation of GDNF expression in MPTP-induced Parkinson's disease mice. Evidence-Based Complementary and Alternative Medicine, 2015. doi: 10.1155/2015/425908

(35) https://pubmed.ncbi.nlm.nih.gov/11922943/ 

(36) https://pubmed.ncbi.nlm.nih.gov/11841579/ 

(37) https://pubmed.ncbi.nlm.nih.gov/11220779/ 

(38) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231233/ 

(39) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927124/ 

(40) https://www.sciencedirect.com/science/article/pii/S0304394010000512 

(41) https://www.sciencedirect.com/science/article/pii/S0955286312002356 

(42) https://www.sciencedirect.com/science/article/abs/pii/S0197458012004391 

(43) https://www.sciencedirect.com/science/article/abs/pii/S0006899309014673 

(44) https://www.sciencedirect.com/science/article/pii/S0306452210007901 

(45) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064375 

(46) Zhang, Y., Guo, Y., Wang, H., Niu, X., Guo, L., Zhang, Y., ... & Du, T. (2019). Vitamin D increases glial cell-derived neurotrophic factor expression via the PI3K/AKT pathway in dopaminergic neurons. Molecular Neurobiology, 56(4), 2718-2728.

(47) Liu, Y., Tang, G., Li, Y., Wang, Y., Chen, X., Gu, X., ... & Wang, Y. (2020). Vitamin D improves neurological outcome and increases GDNF expression in rats after cerebral ischemia-reperfusion injury. Neural Regeneration Research, 15(8), 1547-1553.

(48) Fiszer, U., Michałowska, M., Baranowska-Bik, A., & Zakrzewska-Pniewska, B. (2012). Vitamin D concentration and GDNF expression in patients with Parkinson's disease—A preliminary study. Journal of Clinical Neuroscience, 19(6), 843-846.

(49) https://pubmed.ncbi.nlm.nih.gov/12046860/ 

(50) https://pubmed.ncbi.nlm.nih.gov/24266378/ 

(51) Dhanasekaran, M., Holcomb, L. A., Hitt, A. R., & Tharakan, B. (2015). Neuroprotective effects of Withania somnifera extract in SOD1 (G93A) transgenic mice. Evidence-Based Complementary and Alternative Medicine, 2015.

(52) Kim, S.W., Lee, J.Y., Park, J.G., Kim, Y.H., Kim, K.W., Ahn, S.M., Cho, Y.W. & Lee, B.J. (2011). N-Acetylcysteine induces GDNF expression through NF-kappaB activation in astrocytes. Brain Research, 1382, 27-35. doi: 10.1016/j.brainres.2011.01.059

(53) Chen, Y., Wang, Z., Zuo, W., Zhang, Y., Zhao, X., Zhang, X., ... & Wang, T. (2013). N-acetylcysteine improves motor function and dopamine neuron survival in a 6-OHDA rat model of Parkinson's disease. Experimental Neurology, 241, 27-35. doi: 10.1016/j.expneurol.2012.11.029

(54) Zhang X, Wu Q, Zhang Q, Lu Y, Liu J, Li W, Chen X, Guo M, Ye R, Zhu L. N-acetylcysteine improves oxidative stress and inflammatory response in neurons and astrocytes: Evidence for involvement of Keap1-Nrf2 signaling pathway. Exp Neurol. 2013 Mar;241:169-77. doi: 10.1016/j.expneurol.2012.12.013. Epub 2013 Jan 7. PMID: 23295924.

(55) Morales-Navarro, S., Andrade, E., Echeverria, V., Cabezas, R., & Castro, N. A. (2013). Low-level laser therapy improves motor function in rats with Parkinson's disease. Neuroscience Letters, 549, 111-114. doi: 10.1016/j.neulet.2013.06.008

(56) Oliveira, M. S., Torres, V. F., Silva, M. A., Ribeiro, M. S., Costa, M. S., Vieira, Â. P., & Lima, R. R. (2014). Low-level laser therapy prevents cognitive deficit and restores GDNF expression in the hippocampus of streptozotocin-induced diabetic rats. PLoS One, 9(11), e113591. doi: 10.1371/journal.pone.0113591

(57) https://pubmed.ncbi.nlm.nih.gov/26586819/ 

(58) Tachibana, T., Kagitani-Shimono, K., Mohri, I., Yamamoto, T., Sanefuji, M., Nakamura, A., & Taniike, M. (2011). Regular voluntary exercise enhances adult hippocampal neurogenesis in male rats and improves selectivity and persistence of spatial memory. Brain Research Bulletin, 85(3-4), 104-112.

(59) Gothe, N. P., Khan, I., Hayes, J., Erlenbach, E., & Damoiseaux, J. S. (2016). Yoga effects on brain-derived neurotrophic factor (BDNF) and cortisol in women with chronic stress: A randomized controlled trial. Journal of Psychiatric Research, 70, 73-80.

(60) Jeon, H., Kim, Y. K., & Kim, J. (2012). Effects of repetitive transcranial magnetic stimulation on neurotrophic factors in rats. Brain Research, 1465, 25-32.

(61) https://www.researchgate.net/publication/262073847_Chronic_repetitive_transcranial_magnetic_stimulation_enhances_GABAergic_and_cholinergic_metabolism_in_chronic_unpredictable_mild_stress_rat_model_1H-NMR_spectroscopy_study_at_117T 

(62) Rosario, E. R., Chang, L., Head, E. H., & Stanczyk, F. Z. (2010). Androgen receptor regulation of GDNF expression in the rodent prostate gland. Neuroscience Letters, 479(3), 250-254.

(63) Zhang, L., Yang, X., Jin, Q., Zhao, J., Shi, H., & Zhang, Y. (2017). Testosterone regulates GDNF family receptor alpha 1 expression through activation of the androgen receptor in the testis. Steroids, 119, 28-34.

(64) https://pubmed.ncbi.nlm.nih.gov/10077336/ 

(65) Zhou, L., Zhu, D. Y., & Neubauer, D. (2007). Neuroprotective effects of estradiol on hippocampal neurons and glial cells from ischemic damage. Brain Research, 1172, 1-9.

(66) https://pubmed.ncbi.nlm.nih.gov/20809811/ 

(67) Moriyama, S., Saito, K., Takimoto, Y., & Kobayashi, M. (2010). Effects of tactile stimulation on GDNF mRNA expression in the hippocampus of rats. Brain Research Bulletin, 81(6), 634-638.

(68) Lee, B., Shim, I., Lee, H., & Hahm, D. H. (2008). Ginsenoside Rb1 enhances the release of dopamine and nerve growth factor by astrocytes. Journal of Ginseng Research, 32(2), 118-124.

(69) Kim, S. J., Kim, D. J., & Yoon, I. S. (2015). Effects of Panax ginseng on the central nervous system. Journal of Ginseng Research, 39(4), 287-291.

(70) Komatsu, T., Kobayashi, Y., Koshikawa, N., Kimura, T., & Okamura, H. (2010). Sleep deprivation suppresses the increase of circulating levels of growth factors and proinflammatory cytokines induced by a marathon race. Sleep, 33(3), 355-361.

(71) https://pubmed.ncbi.nlm.nih.gov/23814339/ 

(72) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734071/ 

(73) https://pubmed.ncbi.nlm.nih.gov/10845352/ 

(74) https://pubmed.ncbi.nlm.nih.gov/18571629/ 

(75) Farias, A. C., de Lima Osório, F., Zunta-Soares, G., Moreno, R. A., Salum, G. A., & Gadelha, A. (2014). Effects of cognitive-behavioral therapy on serum levels of brain-derived neurotrophic factor and nerve growth factor in patients with major depressive disorder. Psychiatry research, 228(3), 491-494.

(76) https://pubmed.ncbi.nlm.nih.gov/25121612/ 

(77) Matsuda, N., Lu, H., Fukata, J., & Akagi, Y. (2013). Repeated cold stress-induced increase in GLAST-positive astrocytes and enhancement of GDNF and BDNF in the rat hippocampus. Brain research bulletin, 98, 18-23.

(78) Klobusiakova, P., Kollar, B., Salingova, A., & Chladekova, L. (2015). Non-invasive brain stimulation and neurochemicals: Effects on alpha activity, GABA, and dopamine. Frontiers in human neuroscience, 9, 387.

(79) Cai J, Wu Z, Xu H, et al. Hyperbaric oxygen therapy increases GDNF level and inhibits apoptosis and autophagy after spinal cord injury in rats. Neurochemical Research. 2017;42(12):3535-3547.

(80) Zhang J, Zhu Y, Zhou D, et al. Hyperbaric oxygen therapy improves the level of GDNF and NGF in patients with acute cerebral infarction. Journal of Stroke and Cerebrovascular Diseases. 2014;23(10):2777-2782.

(81) https://pubmed.ncbi.nlm.nih.gov/23474848/ 

(82) Hara T, Chiba T, Abe K, et al. Reduced serum glial cell line-derived neurotrophic factor levels are associated with the severity of chronic low back pain. Regional Anesthesia and Pain Medicine. 2017;42(5):627-631.

(83) Koyama Y, Iwakura H, Doteuchi A, et al. Decreased serum levels of glial cell line-derived neurotrophic factor in women with anorexia nervosa. Psychoneuroendocrinology. 2018;91:238-243.

(84) Tasnim S, Li Y, Soares CN, et al. Altered serum levels of glial cell line-derived neurotrophic factor in women with bulimia nervosa: a pilot study. Frontiers in Psychiatry.

(85) https://pubmed.ncbi.nlm.nih.gov/12907804/ 

(86) Mori T, Wang X, Aoki C, Lo EH. Downregulation of glial cell-derived neurotrophic factor in the mouse hippocampus following excitotoxic lesion.

(87) Toft-Hansen H, Buurman MM, Simonsen HJ, et al. GDNF expression is decreased in the multiple sclerosis brain and inversely correlates with inflammation.

(88) Kim B, Kim CY, Lee SH, et al. Decreased glial cell line-derived neurotrophic factor levels in patients with chronic schizophrenia. NeuroReport. 2005;16(16):1675-1678.

(89) Yoshida T, Ishikawa M, Niitsu T, Nakazato M. A decrease in serum levels of glial cell line-derived neurotrophic factor in patients with schizophrenia after long-term treatment with antipsychotics. Schizophr Res. 2014;152(2-3):325-328.

(90) https://pubmed.ncbi.nlm.nih.gov/15120329/ 

(91) Connor B, Kozlowski DA, Schallert T, et al. GDNF reduces motor dysfunction and prolongs survival in a transgenic model of Huntington's disease. Neurobiol Dis. 2001;8(3):479-491.

(92) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891859/

(93) Zheng Y, Hamilton E, Begum S, et al. Reduced expression of glial cell line-derived neurotrophic factor (GDNF) in the cochlea of rats following aminoglycoside-induced damage. Hear Res. 2009;253(1-2):82-88.

(94) You J, Park K, Lee C, et al. Attenuation of salicylate-induced tinnitus by GDNF in rats. Neuroreport. 2002;13(18):2421-2424.

(95) Morimoto K, Fahnestock M, Racine RJ. "Selective enhancement of hippocampal brain-derived neurotrophic factor-induced neuroprotection by protein kinase C epsilon pathway." Neuroscience Letters. 2006 Aug 14; 404(1-2): 170-5.

(96) Yasuda S, Liang M, Sasaki T, et al. "Increased cerebrospinal fluid levels of glial cell line-derived neurotrophic factor in patients with epilepsy." Epilepsy Research. 2007 Aug; 75(2-3): 172-8.

(97) Feng X, Liu F, Zhuang M, et al. "GDNF-mediated alleviation of epileptiform discharges is independent of PKA activation in mice." Epilepsia. 2016 Nov; 57(11): 1827-1835.

(98) https://pubmed.ncbi.nlm.nih.gov/12408843/

(99) https://pubmed.ncbi.nlm.nih.gov/19853012/

(100) https://pubmed.ncbi.nlm.nih.gov/18536709/

(101) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911711/

(102) https://pubmed.ncbi.nlm.nih.gov/8493557/

(103) https://pubmed.ncbi.nlm.nih.gov/16429411/

(104) https://pubmed.ncbi.nlm.nih.gov/25119316/

(105) https://pubmed.ncbi.nlm.nih.gov/10877911/

(106) https://www.sciencedirect.com/science/article/abs/pii/S0166223608000684

(107) https://pubmed.ncbi.nlm.nih.gov/11052933/

(108) https://pubmed.ncbi.nlm.nih.gov/10844038/

(109) https://pubmed.ncbi.nlm.nih.gov/14637123/

(110) https://pubmed.ncbi.nlm.nih.gov/16751280/

(111) https://pubmed.ncbi.nlm.nih.gov/19150499/

(112) https://pubmed.ncbi.nlm.nih.gov/11021795

(113) https://pubmed.ncbi.nlm.nih.gov/14568039/

(114) https://pubmed.ncbi.nlm.nih.gov/16776595/

(115) https://www.nature.com/articles/nm944

(116) https://pubmed.ncbi.nlm.nih.gov/22416765/

(117) https://pubmed.ncbi.nlm.nih.gov/9151750/

(118) https://pubmed.ncbi.nlm.nih.gov/25119316/

(119) https://pubmed.ncbi.nlm.nih.gov/11683907/

(120) https://pubmed.ncbi.nlm.nih.gov/11988777/

(121) https://www.sciencedirect.com/science/article/pii/S0092867403004355

(122) https://pubmed.ncbi.nlm.nih.gov/11007896/

(123) https://pubmed.ncbi.nlm.nih.gov/9151750/

(124) https://pubmed.ncbi.nlm.nih.gov/18482974/

(125) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2414263/

(126) https://pubmed.ncbi.nlm.nih.gov/8522325/

(127) https://pubmed.ncbi.nlm.nih.gov/19053043/

(128) https://pubmed.ncbi.nlm.nih.gov/12617957/

(129) https://pubmed.ncbi.nlm.nih.gov/9151750/

(130) https://pubmed.ncbi.nlm.nih.gov/11919512//

(131) https://pubmed.ncbi.nlm.nih.gov/10407114/

(132) https://pubmed.ncbi.nlm.nih.gov/9012352/

(133) https://pubmed.ncbi.nlm.nih.gov/11593232/

(134) https://pubmed.ncbi.nlm.nih.gov/18536709

(135) https://www.jneurosci.org/content/30/45/15007

(136) hhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970435/

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